National Swine Resource and Research Center

描述（由申请人提供）：本申请的总体目标是继续国家养猪资源和研究中心（NSRRC）的运作。到目前为止，NSRRC刚刚开始了它的第四个年头，它已经成功地开发了基础设施，以协助跨多个学科的猪为基础的研究。在功能上，NSRRC一直积极参与招募和进口猪模型到该中心，并向美国各地的研究人员分发细胞、组织、器官和猪。NSRRC还为研究界提供了宝贵的服务，通过创建研究人员所需的新型转基因猪模型，以及通过培训和教育科学家在生物医学研究中使用猪。重要的是，我们已经建立了一个全新的国家养猪中心大楼，拥有最先进的高生物安全性，以容纳NSRRC的所有功能。下一资助期的具体目标如下：

DESCRIPTION (provided by applicant): The overall goal of this application is to continue operation of the National Swine Resource and Research Center (NSRRC). To date, the NSRRC is just beginning its fourth year of operation and it has successfully developed the infrastructure needed to assist swine-based research across multiple disciplines. Functionally the NSRRC has been actively engaged in recruiting and importing swine models into the Center and in distributing cells, tissues, organs and pigs to investigators throughout the United States. The NSRRC also provides invaluable services to the research community by creating new genetically-modified swine models needed by investigators and by training and educating scientists regarding the use of swine in biomedical research. Importantly, we have built an entirely new National Swine Center building, with state-of-the-art high biosecurity, to house all of the functions of the NSRRC. The Specific Aims for the upcoming grant period are as follows: Specific Aims: 1. To operate the National Swine Research and Resource Center. Functions of the NSRRC will continue to include: (a) importation of existing swine models of human health and disease, (b) rederivation of pigs to eliminate pathogens and health monitoring to assure maintenance of a pathogen-free status, (c) cryopreservation and storage of gametes, embryos and somatic cells to prevent future loss of valuable models, (d) distribution of reagents, cells, tissues, organs and designated pathogen-free pigs, and (e) creation of new genetically-modified pigs needed by the biomedical research community. 2. To perform innovative research that will benefit the NSRRC and the biomedical research community. Research projects are aimed at improving: a) the cryopreservation of pig reproductive cells and tissues; b) developing state-of-the-art serologic testing methods for swine health surveillance; and c) the development of improved methods for the production of genetically-modified pigs. The NSRRC will also serve as a site for training and educational activities related to research employing swine models.