MULTIPARAMETER FLOW CYTOMETRIC ANALYSIS OF SOLID TUMORS

实体瘤的多参数流式细胞术分析

• 批准号: 2100899
• 负责人: CARLETON C STEWART
• 金额: $ 8.45万
• 依托单位: ROSWELL PARK CANCER INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-23 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2100899
• 关键词: CD antigens; biomarker; bladder neoplasm; breast neoplasm /cancer diagnosis; breast neoplasms; cathepsin B; cellular oncology; diploidy; estrogen receptors; female; flow cytometry; histopathology; human subject; keratin; neoplasm /cancer diagnosis; neoplasm /cancer genetics; oncogenes; progesterone receptors; prognosis

The studies involving multiparameter analysis of solid tumors is focused on breast and bladder cancer. DNA content alone, while promising, has not proven to be clinically useful for establishing prognosis in individual patients. The hypothesis of these studies is that combination of DNA ploidy with other markers will stratify patients into useful prognostic groups. This project has two specific aims: (1). "In breast cancer develop panels for the simultaneous measurement of cytokeratin, estrogen receptor and erbs-2 and cathepsin S. progesterone receptor and cathepsin C. (2). "To develop a test for the detection of bladder cancer using cytokeratin, CD45 and myc."

实体瘤的多参数分析是目前研究的热点。 关于乳腺癌和膀胱癌。单凭DNA含量，虽然前景看好，但也有 未被证明在临床上对确定预后有用 个别病人。这些研究的假设是 DNA倍体与其他标记的结合将使患者分层为 有用的预见组。该项目有两个具体目标：(1)。“在 乳腺癌开发出同时测量 细胞角蛋白、雌激素受体、ERBS-2和组织蛋白酶S.孕酮 受体和组织蛋白酶C(2)。“开发一种检测病毒的方法 使用细胞角蛋白、CD45和myc治疗膀胱癌。