ORGANOCHLORINE RESIDUE LEVELS AND RISK OF BREAST CANCER

有机氯残留水平和乳腺癌风险

• 批准号: 2156187
• 负责人: Matthew P Longnecker
• 金额: $ 18.9万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2156187
• 关键词: African American; blood chemistry; blood lipid; breast neoplasms; cancer risk; chemical carcinogen; chemical related neoplasm /cancer; chlordane; chlorohydrocarbon insecticide; dichlorodiphenyltrichloroethane; dioxins; environmental toxicology; female; halobiphenyl /halotriphenyl compound; human middle age (35-64); human subject; insecticide biological effect; interview; pesticide interaction; statistics /biometry; women's health; young adult human (21-34)

Organochlorine compounds such as DDT and PCB are detectable in the blood of most Americans. These compounds have been designated as possibly or probably carcinogenic by the International Agency for Research on Cancer. Some recent reports suggest that risk of breast cancer is proportional to exposure to DDE, a degradation product of DDT, and to PCB. These reports were each based on fewer than 60 cases. Results from another, larger study suggest no associations exist; additional data are needed. African- Americans have had greater exposure to DDE than white Americans, thus an examination of the DDE-breast cancer association in African-Americans may have greater statistical power to detect an effect than studies in lesser- exposed populations. We propose to conduct a case-control study to test the hypothesis that levels of organochlorine residues in serum are associated with increased risk of breast cancer among African-American women. The study will be added on to ongoing study funded by the National Institute of Child Health and Development. The ongoing study, the Women's Contraceptive and Reproductive Experience (CARE) study, is a multi-center population-based case-control study being conducted among women aged 35-64 in five areas of the U.S., including Los Angeles County. For the present study, we will enroll a subset of the African-American participants in Los Angeles County. Cases will be identified through the Los Angeles County Cancer Surveillance Program (a SEER cancer registry).. Controls will be selected by random-digit dialing. After subjects have completed interviews for the Women's CARE study, they will be asked to provide a blood specimen for the present study. We will obtain blood from 300 African-American breast cancer cases and 300 controls and measure serum organochlorine residues (DDE, PCBs, heptachlor epoxide, oxychlordane, trans-nonachlor, dieldrin, HCB, and beta-BHC) and total lipids using standard methods. Serum residue levels will be examined in relation to odds of breast cancer in multivariate unconditional logistic regression models.

血液中可检测到滴滴涕和多氯联苯等有机氯化合物。 对大多数美国人来说。这些化合物已被指定为可能或 可能是国际癌症研究机构的致癌物质。 最近的一些报告表明，患乳腺癌的风险与 接触滴滴涕的降解产物DDE和多氯联苯。这些报告 每个都是基于不到60个案例。来自另一项更大规模研究的结果 建议不存在关联；需要其他数据。非洲-- 美国人比美国白人更容易接触DDE，因此 对非裔美国人中DDE-乳腺癌协会的检查可能会 有更大的统计能力来检测一种影响，而不是在较小的 暴露的人群。 我们建议进行一项病例对照研究，以检验以下假设 血清中有机氯残留物水平与 非裔美国女性患乳腺癌的风险。这项研究将是 补充到由国家儿童健康研究所资助的正在进行的研究 和发展。正在进行的研究，妇女避孕药和 生殖体验(CARE)研究是一项以多中心人群为基础的研究 在35岁-地区的五个地区正在进行的病例对照研究 美国，包括洛杉矶县。在目前的研究中，我们将 在洛杉矶招收非裔美国人参与者的子集 县里。病例将通过洛杉矶县癌症中心确认 监视计划(SEER癌症登记)..将选择控件 通过随机数字拨号。在受试者完成了对 妇女关怀研究，她们将被要求提供血液样本 目前的研究。 我们将从300名非裔美国人乳腺癌患者和300名 控制和测量血清有机氯残留(DDE、多氯联苯、七氯 环氧化物、环氧氯丹、反式二十三氯、狄氏剂、六氯苯和贝塔-六六六)和 用标准方法测定总脂类。血清残留水平将是 多因素分析与乳腺癌发病风险的关系 无条件Logistic回归模型。