HUMAN HEALTH EFFECTS OF EXPOSURE TO ORGANOCHLORINE COMPOUNDS

接触有机氯化合物对人类健康的影响

• 批准号: 6432322
• 负责人: Matthew P Longnecker
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6432322
• 关键词: African American; clinical research; dichlorodiphenyltrichloroethane; embryo /fetus toxicology; environment related neoplasm /cancer; environmental toxicology; halobiphenyl /halotriphenyl compound; human subject; neoplasm /cancer epidemiology; outcomes research; pesticide biological effect

Aims: Persistent halogenated organic pollutants (e.g., DDT, PCBs [polychlorinated biphenyls], dioxin) command special attention in public health because they are ubiquitous in the ecosystem and may be causing adverse human health effects at background levels of exposure, via diet. We are conducting several studies of the human health effects of background exposure to organochlorines. Accomplishments: We have completed field work on a case-control study of serum p,p'-DDE (a metabolite of DDT) and PCB levels in relation to risk of breast cancer among African-American women in Los Angeles. Laboratory results are complete (300 cases and 300 controls), and the data are being prepared for analysis and will be ready for analysis in 2000. Our main project is an investigation of health effects of in utero exposure to organochlorine residues among participants in the Collaborative Perinatal Project, for whom a specimen bank (mother's serum) is available. Associations being examined are: 1) mother's p,p'-DDE levels in relation to risk of hypospadias, cryptorchidism, and polythelia in male offspring, 2) mother's PCB level in relation to child's neurodevelopmental outcomes, hearing, and IQ, 3) mother's DDE level in relation to body habitus in adolescence in male offspring. Laboratory analyses are now complete for over 2,500 subjects and the data are being cleaned for analysis, which will begin in 2000. We also examined in utero PCB exposure in relation to neonatal thryoid function in the North Carolina cohort study of effects of early-life organochlorine exposure. We have collaborated with investigators from the Air Force Health Study to examine health effects of dioxin exposure, including diabetes. We are beginning work on a study of the effect of the antiandrogen DDE on anthropometric measures at birth among neonates from a highly exposed population in Mexico.

目标：持久性卤化有机污染物（例如，滴滴涕、多氯联苯[多氯联苯]、二恶英）在公共卫生中需要特别关注，因为它们在生态系统中无处不在，在本底水平的接触下，通过饮食可能对人类健康造成不利影响。 我们正在进行几项关于接触有机氯对人体健康影响的研究。成绩：我们已经完成了一项关于血清p，p '-DDE（DDT的一种代谢物）和PCB水平与洛杉矶非裔美国妇女乳腺癌风险之间关系的病例对照研究的实地工作。 实验室结果已经完成（300个病例和300个对照），正在准备数据供分析，并将于2000年准备好供分析。我们的主要项目是调查围产期合作项目参与者在子宫内接触有机氯残留物对健康的影响，为他们提供了一个样本库（母亲的血清）。 正在审查的协会有：1）母亲的p，p '-DDE水平与男性后代尿道下裂、隐睾症和多囊症的风险有关，2）母亲的PCB水平与儿童的神经发育结果、听力和智商有关，3）母亲的DDE水平与男性后代青春期的体型有关。 目前已完成对2 500多名受试者的实验室分析，并正在清理数据，以便进行分析，分析工作将于2000年开始。 在北卡罗来纳州的队列研究中，我们还研究了宫内PCB暴露与新生儿甲状腺功能的关系。我们与空军健康研究的调查人员合作，研究二恶英暴露对健康的影响，包括糖尿病。我们正在开始研究抗雄激素DDE对墨西哥高暴露人群新生儿出生时人体测量指标的影响。