Studies Of Phenolphthalein Containing Laxative Use

大约3%的美国老年人口每天使用含有酚酞的泻药。在人类中，我们调查了含有酚酞的泻药使用与卵巢癌和腺瘤性结直肠息肉风险的关系。卵巢癌是在NTP动物身上观察到的一种特殊形式的癌症，但很少有流行病学研究研究卵巢癌的风险与使用泻药有关。因此，我们进行了两项病例对照研究，以评估含酚酞类泻药的使用与卵巢癌风险的关系。两项研究都没有显示出强有力的证据表明两者之间存在联系。 去年的进展：发表了系列期末论文

Phenolphthalein, a constituent in many laxatives, showed clear evidence of carcinogenic activity in 2-year feeding studies in rodents done by the National Toxicology Program (NTP). Phenolphthalein-containing laxatives, which have been shown to be carcinogenic in laboratory animals at doses only 10-fold greater than those frequently consumed by humans, have recently been on the market and widely used. About 3% of the older U.S. population uses phenolphthalein-containing laxatives on a daily basis. We investigated the relation of phenolphthalein-containing laxative use with risk of ovarian cancer and adenomatous colorectal polyps in humans. Ovarian cancer was one of the specific forms of cancer observed in the NTP animal, but few epidemiologic studies have examined ovarian cancer risk in relation to laxative use. Therefore, we conducted two case-control studies to evaluate the relation of phenolphthalein-containing laxative use with risk of ovarian cancer. Neither study showed strong evidence of an association. Last year's progress: Final paper in series was published