Studies Of Phenolphthalein Containing Laxative Use

含酚酞缓泻剂用途的研究

• 批准号: 7007385
• 负责人: Matthew P Longnecker
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7007385
• 关键词: adenomatous polyps; anorectal disorder; cancer risk; clinical research; colon polyp; colorectal neoplasms; drug carcinogenesis; drug related neoplasm /cancer; human subject; interview; laxative; ovary neoplasms; phenols; questionnaires; toxicology

Phenolphthalein, a constituent in many laxatives, showed clear evidence of carcinogenic activity in 2-year feeding studies in rodents done by the National Toxicology Program (NTP). Phenolphthalein-containing laxatives, which have been shown to be carcinogenic in laboratory animals at doses only 10-fold greater than those frequently consumed by humans, have recently been on the market and widely used. About 3% of the older U.S. population uses phenolphthalein-containing laxatives on a daily basis. We investigated the relation of phenolphthalein-containing laxative use with risk of ovarian cancer and adenomatous colorectal polyps in humans. Ovarian cancer was one of the specific forms of cancer observed in the NTP animal, but few epidemiologic studies have examined ovarian cancer risk in relation to laxative use. Therefore, we conducted two case-control studies to evaluate the relation of phenolphthalein-containing laxative use with risk of ovarian cancer. Neither study showed strong evidence of an association. Last year's progress: Final paper in series was published

在国家毒理学计划（NTP）对啮齿动物进行的2年喂养研究中，酚酞（许多泻药中的一种成分）显示出明确的致癌活性证据。含有酚酞的泻药，已被证明是致癌的实验室动物剂量只有10倍以上的人经常消耗，最近已在市场上广泛使用。大约3%的美国老年人每天使用含酚酞的泻药。我们研究了人类使用含酚酞的泻药与卵巢癌和腺瘤性结直肠息肉风险的关系。卵巢癌是在NTP动物中观察到的特定癌症形式之一，但很少有流行病学研究检查卵巢癌风险与泻药使用的关系。因此，我们进行了两项病例对照研究，以评估含酚酞的泻药使用与卵巢癌风险的关系。两项研究都没有显示出强有力的证据。 去年的进展：发表了系列最后论文

项目成果

Risk of ovarian cancer in relation to use of phenolphthalein-containing laxatives.

• DOI: 10.1054/bjoc.2000.1250
• 发表时间: 2000-08
• 期刊: British journal of cancer
• 影响因子: 8.8
• 作者: Cooper GS;Longnecker MP;Sandler DP;Ness RB
• 通讯作者: Ness RB