Effect Of Diet and Other Early Exposures on Child Health

饮食和其他早期暴露对儿童健康的影响

• 批准号: 7169663
• 负责人: Matthew P Longnecker
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7169663
• 关键词: chronic disease /disorder; clinical research; cryptorchidism; dentistry; developmental neurobiology; developmental nutrition; dietary constituent; disease /disorder proneness /risk; endocrinology; environmental exposure; human subject; mother /embryo /fetus nutrition; nutrition related tag; questionnaires; racial /ethnic difference; reproductive hormone

Diet and other early exposures may affect child development and the risk of several chronic diseases, but additional research is needed. The current research described in this "catch-all" project comprises two subprojects: first, a study of effects due to exposures incurred secondary to dental procedures and treatments during pregnancy, and second, a group of inter-related studies all having to do with hormone levels in women during pregnancy in relation to factors such as race and cryptorchidism in offspring, which are risk factors for testicular germ cell tumors. The study of effects due to exposures incurred secondary to dental procedures and treatments during pregnancy is based on data from the Avon Longitudinal Study of Parents and Children. Data on dental history were available for 8,251 women and the outcomes examined were birth weight, preterm birth, and child's communicative development. Regarding the studies of hormone levels during pregnancy, these were all nested in the Collaborative Perinatal Project (CPP--see description under project ES049016). Stored serum from pregnant women was analyzed for hormone levels and examined in relation to subject characteristics. Last year's progress: A manuscript describing the dental study was prepared and will be submitted to a journal shortly. Two papers on hormone levels in pregnancy were published, and one was submitted to a journal.

饮食和其他早期暴露可能会影响儿童发育和几种慢性疾病的风险，但需要进行更多的研究。 在这个“包罗万象”的项目中描述的当前研究包括两个子项目：第一，由于怀孕期间牙科手术和治疗引起的暴露的影响的研究，第二，一组相互关联的研究都与怀孕期间女性的激素水平有关，这些激素水平与种族和后代隐睾症等因素有关，这些因素是睾丸生殖细胞肿瘤的风险因素。 对怀孕期间牙科手术和治疗引起的继发性暴露的影响的研究是基于雅芳父母和儿童纵向研究的数据。8，251名妇女的牙科史数据可用，检查的结果是出生体重，早产和儿童的沟通发展。 关于怀孕期间激素水平的研究，这些研究都纳入围产期合作项目（CPP-见项目ES 049016下的说明）。分析储存的孕妇血清的激素水平，并检查与受试者特征的关系。 去年的进展： 一份描述牙科研究的手稿已经准备好，不久将提交给一份杂志。发表了两篇关于怀孕期间激素水平的论文，其中一篇提交给了一份期刊。