HUMAN HEALTH EFFECTS OF EXPOSURE TO ORGANOCHLORINE COMPOUNDS

接触有机氯化合物对人类健康的影响

• 批准号: 6289981
• 负责人: Matthew P Longnecker
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289981
• 关键词: African American; clinical research; dichlorodiphenyltrichloroethane; embryo /fetus toxicology; environment related neoplasm /cancer; environmental toxicology; halobiphenyl /halotriphenyl compound; human subject; neoplasm /cancer epidemiology; outcomes research; pesticide biological effect

Persistent halogenated organic pollutants (e.g., DDT, PCBs [polychlorinated biphenyls], dioxin) command special attention in public health because they are ubiquitous in the ecosystem and may be causing adverse human health effects at background levels of exposure, via diet. We are conducting several studies of the human health effects of background exposure to organochlorines. We have completed field work on a case-control study of serum p,p-DDE (a metabolite of DDT) and PCB levels in relation to risk of breast cancer among African-American women in Los Angeles. Three hundred cases and 300 controls have been enrolled, and the data will be prepared for analysis in 1999. Our main project is an investigation of health effects of in utero exposure to organochlorine residues among participants in the Collaborative Perinatal Project, for whom a specimen bank (mothers serum) is available. Associations being examined are: 1) mothers p,p-DDE levels in relation to risk of hypospadias, cryptorchidism, and polythelia in male offspring, 2) mothers PCB level in relation to childs neurodevelopmental outcomes, hearing, and IQ, 3) mothers DDE level in relation to body habitus in adolescence in male offspring. We are also examining in utero PCB exposure in relation to neonatal thryoid function in the North Carolina cohort study of effects of early-life organochlorine exposure (Rogan/Gladen study), and are collaborating with investigators from the Air Force Health Study to examine health effects of dioxin exposure. - PCBs, DDE, Cryptorchidism, Hypospadias, Breast neoplasms, Neurodevelopment, IQ, Thyroid - Human Subjects

持久性卤化有机污染物（例如，滴滴涕、多氯联苯[多氯联苯]、二恶英）在公共卫生中需要特别关注，因为它们在生态系统中无处不在，在本底水平的接触下，通过饮食可能对人类健康造成不利影响。我们正在进行几项关于接触有机氯对人体健康影响的研究。我们已经完成了洛杉矶非裔美国妇女血清p，p-DDE（DDT的代谢物）和PCB水平与乳腺癌风险相关的病例对照研究的现场工作。已登记了300例病例和300例对照，将在1999年准备数据供分析。我们的主要项目是调查围产期合作项目参与者宫内接触有机氯残留物对健康的影响，为他们提供了一个样本库（母亲血清）。正在审查的协会有：1）母亲p，p-DDE水平与男性后代尿道下裂、隐睾症和多囊症的风险有关; 2）母亲PCB水平与查尔兹儿童神经发育结果、听力和智商有关; 3）母亲DDE水平与男性后代青春期体型有关。我们还在北卡罗来纳州对生命早期有机氯暴露影响的队列研究（罗根/格拉登研究）中检查子宫内多氯联苯暴露与新生儿甲状腺功能的关系，并与空军健康研究的调查人员合作，检查二恶英暴露对健康的影响。- 多氯联苯、DDE、隐睾症、尿道下裂、乳腺肿瘤、神经发育、智商、甲状腺-人类受试者