MULTIDIMENSIONAL DYNAMICS OF THE VESTIBULO-OCULAR REFLEX

一种新的概念性方法模拟视觉-前庭相互作用和 发展了三维速度存储技术。的基础 该方法是速度存储的特征由 其系统矩阵的特征值和特征向量。这一特征 是空间方向的客观度量，并使直接 眼动速度的模型预测与数据比较 重力的作用。该模型已通过实验进行了测试。 视动性眼震(OKN)和视动性后眼震(OKAN) 无论是猴子还是人类。从结果来看，有可能将 速度存储对人的空间知觉的定向 垂直的。基于模型的实验被提出，这将使我们能够 分层移动时速度存储方向的确定 环境，根据收益的适应来表征其定位 前庭-眼反射(VOR)，并找到神经基础 空间定向。关闭后停止后的眼速- 将分析垂直轴旋转(OVAR)以确定空间 方向性受半规管激活的影响，而 具有标题并且受制于先前连续旋转的重力矢量。 我们还将研究速度存储的方向如何受 离心法。这种刺激会旋转力场的方向。 相对于头部，也增加了它的大小。方向感 OVAR后停止后的速度存储参数和 将把离心法与奥坎期间获得的离心法进行比较。这个 VOR的自适应对速度存储定向的影响 也将进行研究。增益眼速度相对于 刺激轴。将确定速度存储是否保持 其与重力相关的取向或适应与增益一致 适应。运动中速度跳跃(VPS)单位的神经基础 前庭核团(VN)。最近的研究表明， OKN、OKAN、VOR和OVAR过程中VO和VPS神经元的放电具有动态性 具有存储速度的特性。侧向射击的频率， 与前、后椎管相关的VO和VPS单位 前庭刺激和视动刺激将被记录下来。平均本征值 并且将与响应曲线相关联的特征向量与 由眼球运动速度得到的数据。我们的假设是，方向 通过分析单位活动获得的参数将与 通过分析单位活动获得的定向参数将 与与眼速相关的方向参数相同。 这项研究应该对空间定向有更好的理解。 运动中的代偿性凝视运动以及定向是如何 受VOR增益自适应的影响。我们也会有一个更清晰的想法 关于前庭系统中的神经组织 速度存储和空间定向编码。

A new conceptual approach to model visual-vestibular interaction and velocity storage in three dimensions has been developed. The basis for the approach is the characterization of velocity storage by the eigenvalues and eigenvectors of its system matrix. This characterization is an objective measure of spatial orientation and enables a direct comparison between model prediction and data of eye velocity as a function of gravity. The model has been tested against experiments on optokinetic nystagmus (OKN) and optokinetic after-nystagmus (OKAN) in both monkeys and humans. From the result, it has been possible to link orientation of velocity storage to human perception of the spatial vertical. Model-based experiments are proposed that will enable us to determine the orientate of velocity storage when moving in a gradational environment, characterize its orientation following adaption of the gain of the vestibulo-ocular reflex (VOR), and find the neural basis for the spatial orientation. Eye velocity following stopping after off- verticals-axis-rotation (OVAR) will be analyzed to determine how spatial orientation is affected by activation of the semicircular canals while titled and being subjected to a prior continuous rotating gravity vector. We will also examine how orientation of velocity storage is affected by centrifugation. This stimulus rotates the direction of the force fields relative to the head and also increases its magnitude. The orientation parameters of velocity storage following stopping after OVAR and centrifugation will be compared to those obtained during OKAN. The affects of adaptation of the VOR on the orientation of velocity storage will also be studied. Gain eye velocity is rotated relative to the stimulus axis. It will be determined whether velocity storage maintains its gravity dependent orientation or adapts coincident with the gain adaption. The neural basis for velocity saccade (VPS) units in the vestibular nuclei (VN). Recent work has shown that the frequency of firing of VO and VPS neurons during OKN, OKAN, VOR, and OVAR has dynamic characteristic of velocity storage. The frequency of firing of lateral, anterior, and posterior canal related VO and VPS units during identical vestibular and optokinetic stimuli will be recorded. Average eigenvalues and eigenvectors associated with the response curves will be compared to those obtained from eye velocity. Our hypothesis is that the orientation parameters obtained by analyzing the unit activity will be the same as the orientation parameters obtained by analyzing the unit activity will be the same as the orientation parameters associated with eye velocity. This research should give a better understanding of spatial orientation of compensatory gaze movement during locomotion and how orientation is affected by gain adaptation of the VOR. We will also have a clearer idea about the neural organization in the vestibular system that produces velocity storage and the coding for spatial orientating.