BEHAVIORAL AND PHYSIOLOGICAL EFFECTS OF 2-DEOXYGLUCOSE INFUSIONS

2-脱氧葡萄糖（2-DG）是竞争性抑制 葡萄糖-6-磷酸脱氢酶，并导致细胞内 葡萄糖缺乏 在以前的研究中，2-DG被用作应激源， 激活下丘脑-垂体-肾上腺（HPA）轴和 交感肾上腺轴和刺激食欲中心的 下丘脑 我们对这种模式的兴趣是由临床产生的。 观察到酗酒者经常消耗更多的 停止饮酒后的碳水化合物。 为了探索 酗酒患者可能存在下丘脑异常，我们 给戒酒的酗酒者服用2-DG， 行为和生理变化引起的2-DG挑战。 我们 假设2-DG诱导的葡萄糖减少反应会引起 神经内分泌和行为的变化， 酒精对下丘脑的作用 结果分析表明， 饮酒者摄入的卡路里比对照组少， 安慰剂给药。 相反，酗酒者表现出夸张的 下丘脑，ACTH对葡萄糖缺乏的反应。

2-deoxyglucose (2-DG) is a glucose analog which competitively inhibits glucose-6-phosphate dehydrogenase and leads to intracellular glucoprivation. In previous studies, 2-DG has been used as a stressor to activate both the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic adrenal axis and stimulate the appetitive centers of the hypothalamus. Our interest in this paradigm was generated by the clinical observation that alcoholics frequently consume increased amounts of carbohydrates following cessation of drinking. In order to explore possible hypothalamic abnormalities in patients with alcoholism, we administered 2-DG to abstinent alcoholics and measured the resulting behavioral and physiological changes arising from the 2-DG challenge. We postulated that a 2-DG induced glucoprivic response would give rise to both neuroendocrine and behavioral changes that might elucidate mechanisms of alcohol's action in the hypothalamus. Analysis of the results show alcoholics consume less calories than controls following both 2-DG and placebo administration. Conversely, alcoholics show an exaggerated hypothalamic, ACTH response to glucoprivation.