RELATIONSHIP OF PSYCHOBIOLOGY TO PSYCHOPATHOLOGY IN ALCOHOLICS

酒精中毒和情感障碍经常发生在同一个人身上 在同一个家庭的成员。 该协会可以代表共同- 由于偶然或由于以下原因而存在两种常见疾病实体（a） 由于潜在情感的自我药物治疗而导致的酒精中毒 障碍，或（B）由酒精滥用的毒性作用引起的抑郁症。 研究表明，酒精可以大大改善情感的感觉， 幸福，但随着持续的醉酒，这种改善可能是 颠倒了 此外，在慢性实验性中毒期间，酗酒者不会 只会变得越来越沮丧，也越来越焦虑。 在该方案中，我们提出了表征某些生化方面的 抑郁和焦虑的症状 为此我们 将检查脑脊液和血浆中的去甲肾上腺素（说谎和 站立），尿中的儿茶酚胺代谢产物，并采用药理学 使用乳酸盐、异丙肾上腺素和氯丙咪嗪的激发模式。

Alcoholism and affective disorders frequently occur in the same individuals and in members of the same family. This association may represent the co- existence of two common disease entities due to chance or due to (a) alcoholism resulting from self medication of an underlying affective disorder, or (b) depression resulting from toxic effects of alcohol abuse. Studies have shown that alcohol may acutely improve the sense of affective well-being, but with continued intoxication this improvement may be reversed. Also, during chronic experimental intoxication, alcoholics not only become increasingly depressed but also more anxious. In this protocol we propose to characterize certain biochemical aspects of depression and anxiety as they occur in alcoholic patients. To do this, we will examine cerebrospinal fluid and plasma for norepinephrine (lying and standing), urine for catecholamine metabolites and employ pharmacological challenge paradigms using lactate, isoproterenol and chlorimipramine.