ENVIRONMENTAL EXPOSURES IN CANCER ETIOLOGY

描述：（根据申请人描述改编）本项目是 关注NPC和HCC的流行病学。 余博士将实施和 在新加坡完成一项对60，000名45-64岁中国人的队列研究。 主要目的是明确建立因果关系 中国咸鱼和类似食物的摄入与NPC之间的关系 如以前的病例对照研究所建议的发展。 更广泛的目标 是建立一个稳定的长期研究队列， 饮食和其他环境决定因素与癌症的关系， 其他慢性病。 其他NPC相关项目包括病例对照 中危地区上海市的流行病学调查及病例对照研究 台湾（中度高风险地区）。 这两项研究是 申请人继续尝试用中文定义NPC病因， 发病率相差20倍。 申请人还将继续 她与生物化学家史蒂文·坦南鲍姆博士和约瑟夫· Landolph，系统地寻找致癌化合物， 中国的咸鱼会导致人类的NPC。 未来研究 HCC病因学将主要涉及一项中年男性队列研究， 上海市（高危人群）和上海市黑人、 洛杉矶县的白色居民（低风险人群）。的目标 这两项研究都是为了阐明独立和互动的作用， B肝炎病毒（HBV）、丙型肝炎病毒（HCV）、酒精和烟草 HCC的发病机制。 上海研究的另一个目标是 研究膳食黄曲霉毒素在肝癌发生中的作用，同时 洛杉矶的研究还旨在研究 激素使用和HCC发展。

DESCRIPTION: (Adapted from the Applicant's Description) This project is concerned with the epidemiology of NPC and HCC. Dr. Yu will implement and complete a cohort study of 60,000 Chinese aged 45-64 years in Singapore. The primary aim is to definitively establish the causal relationship between ingestion of Chinese salted fish and similar foods and NPC development as suggested by previous case-control studies. A broader aim is to establish a stable cohort for the long term study of the relationship of dietary and other environmental determinants to cancer and other chronic diseases. Other NPC related projects include a case-control study in Shanghai (an intermediate risk region) and a case-control study in Taiwan (a moderately high risk region). These two studies are a part of the applicant's continuing attempt to define NPC etiology in Chinese in whom incidence rates vary by 20-fold. The applicant will also continue her collaboration with biochemists, Drs. Steven Tannenbaum and Joseph Landolph, to systematically search for the carcinogenic compound(s) in Chinese salted fish that give rise to NPC in humans. Future research in HCC etiology will mainly involve a cohort study of middle-aged men in Shanghai (a high risk population) and a case-control study among black and white residents of Los Angeles County (a low risk population). A goal of both studies is to elucidate the independent and interactive roles of hepatitis B virus (HBV), hepatitis C virus (HCV), alcohol, and tobacco in the pathogenesis of HCC. The Shanghai study has the additional goal of investigating the role of dietary aflatoxin in hepatocarcinogenesis while the Los Angeles study also aims to examine the relationship between hormone use and HCC development.