SINGAPORE COHORT STUDY OF DIET AND CANCER

新加坡饮食与癌症队列研究

• 批准号: 6951689
• 负责人: Mimi C. Yu
• 金额: $ 17.73万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951689
• 关键词: Chinese; ascorbate; biomarker; breast neoplasms; cancer risk; carotenoids; clinical chemistry; clinical research; colorectal neoplasms; diet; dietary lipid; female; human middle age (35-64); human old age (65+); human subject; isothiocyanates; lung neoplasms; nasopharyngeal neoplasms; neoplasm /cancer epidemiology; nutrition aspect of cancer; nutrition related neoplasm /cancer; nutrition related tag; selenium; soybeans; tocopherols

This is a request for continued funding of a residential cohort of 60,000 Singapore Chinese men and women aged 45-74 years. The cohort was initiated in April 1993. At recruitment, each cohort subject is interviewed in-person by a trained interviewer using a structured questionnaire that focuses on current diet. The cohort has been passively followed for the occurrence of cancer and death through record linkage with the population-based Singapore Cancer Registry and the Singapore Vital Statistics Office. As shown in the grant application, this cost- efficient method of follow-up generates numbers of incident cancers and deaths that are as expected based on age-sex-specific general population rates applied to cumulative person-years of observation of the studied cohort. Beginning in April 1994, a 3 percent random sample of enrolled subjects were re-contacted and asked to provide a blood and spot urine sample. We propose to extend the blood and spot urine collection to 50 percent of all surviving members of the cohort under age 75 years. The expected size of this biospecimen subcohort is approximately 23,000. The availability of blood and urine specimens on cohort members will enable us to employ biochemical markers to assess exposures and to include genetic factors in exposure-disease association studies. A series of diet/cancer analyses will be conducted during the next five years. The aims are (1) to confirm Cantonese salted fish and related foods as major etiologic agents of nasopharyngeal carcinoma (NPC) and high-risk southern Chinese, and to evaluate the possibly beneficial effects of fresh fruit and vegetables and associated micronutrients on NPC development; (2) to determine the independent and interactive roles of dietary isothiocyanates, carotenoids, tocopherols, vitamin C and selenium in lung carcinogenesis, and to evaluate their effects on the smoking/lung cancer association; (3) to determine the roles of dietary soy and various types of dietary fat (total, saturated, monounsaturated, polyunsaturated, n-3 and n-6 fatty acids) in the development of female breast cancer; and (4) to determine the roles of dietary isothiocyanates and soy in the development of colorectal cancer.

这是持续资助住宅队列的60,000名新加坡中国男女45-74岁的要求。该队列于1993年4月启动。在招募时，训练有素的访调员使用侧重于当前饮食的结构化问卷对每个队列对象进行了面对面。 通过与基于人群的新加坡癌症注册中心和新加坡生命统计局的创纪录联系，已被动地遵循该队列的癌症和死亡。 如赠款申请中所示，这种经济高效的随访方法会产生数量的发生癌症和死亡，这些癌症和死亡是根据适用于累积的人年观察所研究队列的累积人年的一般人口率所预期的。从1994年4月开始，重新接触注册受试者的3％随机样本，并要求提供血液和尿液样本。 我们建议将血液和尿液的收集量扩展到75岁以下人群中所有幸存的人群中的50％。 该生物循环亚细胞的预期大小约为23,000。 队列成员的血液和尿液标本的可用性将使我们能够采用生化标记来评估暴露量，并在暴露疾病疾病关联研究中包括遗传因素。未来五年将进行一系列饮食/癌症分析。 目的是（1）确认广东盐盐和相关食品是鼻咽癌（NPC）和高风险南方中国人的主要病因，并评估新鲜水果和蔬菜以及相关的微生酸对NPC发育的有益影响； （2）确定饮食异硫氰酸酯，类胡萝卜素，生育酚，维生素C和硒在肺癌中的独立和互动作用，并评估其对吸烟/肺癌协会的影响； （3）确定饮食大豆和各种类型的饮食脂肪（总饱和，单不饱和，多不饱和，N-3和N-6脂肪酸）在女性乳腺癌发展中的作用； （4）确定异硫氰酸酯和大豆在结直肠癌发展中的作用。