THE SINGAPORE COHORT STUDY OF DIET AND CANCER

新加坡饮食与癌症队列研究

基本信息

批准号：
7258358
负责人：
Mimi C. Yu
金额：
$ 29.66万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-08-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7258358
关键词：
8-hydroxyguanine Address Age Alcohols Animals Area Biological Markers Birth Black Tea Blood Blood Donations CDKN1A gene Carcinogens Case-Control Studies Catechol O-Methyltransferase Caucasoid Race Causations Cell Cycle Checkpoint Cell Cycle Regulation Cells Cessation of life Chemopreventive Agent Chinese People Cohort Studies Collection Colon Colon Carcinoma Colorectal Cancer Complement Consent Consumption Cyclin D1 Cyclin-Dependent Kinases DNA Repair DNA Repair Gene DNA glycosylase DNA ligase IV Data Databases Development Diagnostic Diet Dietary Factors Enzymes Epidemiologic Studies Estrogens Excretory function Female Female Breast Carcinoma Female breast Food Frequencies Funding GSTM1 gene GSTT1 gene Genes Genetic Genus Cola Glutathione S-Transferase Goals Government Health Hormones Human Incidence Individual Intake Interview Interviewer Isothiocyanates Laboratory Study Link Literature London Lung Malignant Neoplasms Malignant neoplasm of lung Mammographic Density Medical History Menopausal Status Metabolism Methods Methylation Mouthwash Numbers OGG1 gene Out-Migrations Participant Pathway interactions Persons Population Predisposition Property Protocols documentation Publications Questionnaires Rate Recontacts Recording of previous events Rectum Registries Reporting Research Design Research Personnel Roentgen Rays Role Sampling Singapore Smoker Source Specimen Spottings Structure Study Subject Tea Telecommunications Telephone Interviews Telephone Number Time Tobacco use Training UDP-Glucuronosyltransferase 1A1 Update Upper digestive tract structure Urine Validation Variant Woman Xeroderma Pigmentosum aged base cancer epidemiology cancer prevention cancer risk cancer site cohort cooking cost cruciferous vegetable diet and cancer drinking enzyme activity experience follow-up glutathione S-transferase M1 human data in vitro Model malignant breast neoplasm member men middle age neoplasm registry non-smoker novel oncoprotein p21 polyphenol programs protective effect repaired sex soy sulfation sulfotransferase urinary

项目摘要

This is a request for continued funding of a residential cohort of 63,257 middle-aged and older (45-74 years) Singapore Chinese men and women accrued between 1993 and 1998. The primary goal of this long-term, population-based cohort study is to elucidate the role of diet and its interaction with genetic factors in the causation of human cancer. At recruitment, each study subject was interviewed in person by a trained interviewer using a structured questionnaire that emphasized current diet assessed via a validated, 165-item food frequency questionnaire. Beginning in April 1994, a random 3% sample of cohort participants were asked to provide blood or buccal cell, and spot urine samples. We extended this biospecimen collection to all surviving cohort participants starting in January 2000. By May 2004, all surviving cohort subjects had been contacted, and biospecimens were collected from 31,318 subjects, representing a consent rate of about 60%. We also asked for blood/buccal/urine specimens from all incident cases of female breast and colorectal cancers beginning in April 1994. To date, the number of cancer cases with pre- or post-diagnostic biospecimens totals 686 (304 female breast, 223 colon, 159 rectum). Between July 1999 and December 2003, all surviving cohort subjects were recontacted for consent to a telephone interview to update information on selected exposures and medical history. Interviews were completed on 52,326 subjects, representing a consent rate of over 90%. The cohort has been passively followed for death and cancer occurrence through regular record linkage with the population-based Singapore Cancer Registry and the Singapore Registry of Births and Deaths. The observed numbers of incident cancers and deaths within the cohort are comparable to corresponding expected numbers based on age-sex-specific incidence rates for all Chinese in Singapore. We will continue to take advantage of this cohort to examine potential cancer protective dietary factors that are rarely consumed among the well-studied occidental populations. Our specific aims for the next 5 years are: (1) to assess the role of tea intake in cancer protection, with consideration for the type of tea drunk (green vs. black tea) and for individual susceptibility factors including key polymorphic genes controlling the 3 major excretion pathways (O-methylation, glucuronidation, sulfation) for tea polyphenols; and (2) to assess the potential roles of genes involved in repair of DMA damage and in cell cycle regulation in modifying a given association between tea as well as other identified dietary protective factors and cancer.

这是要求继续资助63,257个中年和年龄较大（45 - 74年）的新加坡中国男女的住宅队列。在1993年至1998年之间，中国男女。这项长期，基于人群的队列研究的主要目标是阐明饮食及其与人类癌症的遗传因素相互作用的作用及其与遗传因素的作用。在招募时，训练有素的访调员使用结构化问卷对每个研究对象进行了访谈，该问卷强调了通过经过验证的165个项目的食品频率问卷进行评估的当前饮食。从1994年4月开始，要求随机3％的队列参与者提供血液或颊细胞，并进行尿液样本。从2000年1月开始，我们将此生物测量的收集扩展到所有幸存的队列参与者。我们还要求从1994年4月开始的所有女性乳腺癌和结直肠癌事故病例的血液/颊/尿液标本。迄今为止，诊断前或诊断后生物种子的癌症病例的数量为686（304个女性乳房，223个女性乳房，223个结肠癌，159个直肠）。在1999年7月至2003年12月之间，所有尚存的队列受试者均已重新接触电话面试，以更新有关选定暴露和病史的信息。对52,326名受试者的访谈完成了访谈，代表90％以上的同意率。通过与基于人群的新加坡癌症注册中心和新加坡出生和死亡的登记处的常规记录联系，该队列已被动地遵循死亡和癌症的发生。根据新加坡所有中国人的年龄性别特异性发病率，观察到的人群中发生的癌症和死亡人数的数量与相应的预期数量相媲美。我们将继续利用这一队列来检查潜在的癌症保护性饮食因素，这些因素很少在西方人口中被消费。我们未来5年的具体目的是：（1）评估茶摄入量在癌症保护中的作用，并考虑到醉酒的类型（绿色与红茶）以及个人易感因素，包括控制3种主要的排泄途径的关键多态性基因（O-甲基化，葡萄糖糖苷，硫化，硫化）茶多苯酚；（2）评估基因在修复DMA损伤以及细胞周期调节中涉及的潜在作用，并在修饰茶以及其他确定的饮食保护因子和癌症之间的相关性中。