ANALGESICS, DIURETICS, AND RENAL CELL CARCINOMA

镇痛药、利尿剂和肾细胞癌

• 批准号: 6268956
• 负责人: Mimi C. Yu
• 金额: $ 9.65万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6268956
• 关键词: acetaminophen; analgesics; anorexic agent; antiinflammatory agents; aspirin; caffeine; cancer registry /resource; cancer risk; coffee; diuretics; dosage; drug administration rate /duration; drug adverse effect; drug related neoplasm /cancer; human subject; iatrogenic disease; interview; longitudinal human study; medical records; neoplasm /cancer epidemiology; nutrition related neoplasm /cancer; nutrition related tag; occupational hazard; questionnaires; renal cell carcinoma; smoking; statistics /biometry

We propose to continue an ongoing population-based case-control study of renal cell carcinoma in Los Angeles County. The primary aims are: (1) to investigate the relationship between renal cell carcinoma and regular use of analgesics, especially those containing aspirin or other non-steroidal anti-inflammatory agents, or acetaminophen; and (2) to confirm and examine in detail our earlier findings of an association between use of diuretics and diet pills and renal cell carcinoma. The secondary aims are: (1) to further evaluate the association of renal cell carcinoma with cigarette smoking; (2) to determine whether coffee consumption is directly related to an increased risk of renal cell carcinoma; (3) to investigate the possible association between diet and renal cell carcinoma development, especially the consumption of foods rich in nitrosamines or their precursors (enhancing risk) and foods rich in vitamins A and C, and various carotenoids (reducing risk); and (4) to investigate the possible association between occupation and risk of renal cell carcinoma. All histologically confirmed cases of renal cell carcinoma diagnosed between April 1, 1986 and September 30, 1995 who are aged 25-74 years and either Black or White will be asked to participate in this study. Controls will be individually matched to the index case on race, sex, and age (within 5 years), and chosen according to a well-defined procedure from the neighborhood of the index case's residence at the time of cancer diagnosis. We expect to interview about 1280 case-control pairs of renal cell carcinoma.

我们建议继续进行基于人群的案例对照研究 洛杉矶县的肾细胞癌。 主要目的是：（1） 研究肾细胞癌与定期使用之间的关系 镇痛药，尤其是那些含有阿司匹林或其他非甾体类的镇痛药 抗炎剂或对乙酰氨基酚； （2）确认和检查 详细说明我们先前关于使用利尿剂之间关联的发现 以及减肥药和肾细胞癌。 次要目标是：（1） 进一步评估肾细胞癌与香烟的关联 吸烟； （2）确定咖啡消费是否与 肾细胞癌的风险增加； （3）调查可能 饮食与肾细胞癌发展之间的关联，尤其是 富含亚硝胺或其前体的食物消费 （增强风险）和富含维生素A和C的食物，以及各种 类胡萝卜素（降低风险）； （4）调查可能 职业与肾细胞癌风险之间的关联。 全部 组织学确认的肾细胞癌病例已诊断 1986年4月1日和1995年9月30日，年龄25-74岁，要么 将要求黑色或白色参加这项研究。 控件将 与种族，性别和年龄的索引案件单独匹配（在5之内 年），并根据定义明确的程序从 癌症诊断时指数案例住所的邻里。 我们预计将采访大约1280个病例对照对的肾细胞 癌。