ANALGESICS, DIURETICS, AND RENAL CELL CARCINOMA

我们建议继续进行基于人群的病例对照研究， 洛杉矶县的肾细胞癌 主要目标是：（1） 肾细胞癌与规律用药的关系 止痛药，特别是含有阿司匹林或其他非甾体类的止痛药 抗炎药或对乙酰氨基酚;以及（2）确认和检查 我们早期发现利尿剂的使用 减肥药和肾细胞癌 次要目标是：（1） 进一步评估肾细胞癌与吸烟的关系 （2）确定咖啡消费是否与吸烟直接相关; 肾细胞癌的风险增加;（3）调查可能的 饮食与肾细胞癌发生之间的关系， 食用富含亚硝胺或其前体的食物 （增加风险）和富含维生素A和C的食物，以及各种 类胡萝卜素（降低风险）;和（4）调查可能的 职业与肾细胞癌风险之间的关系 所有 经组织学确诊的肾细胞癌病例 1986年4月1日和1995年9月30日，年龄在25-74岁之间， 将要求黑人或白色人参与本研究。 控制将 在种族、性别和年龄上与索引病例单独匹配（在5 年），并根据一个明确的程序从 在癌症诊断时，索引病例的住所附近。 我们预计将访问约1280对病例对照肾细胞 carcinoma.

We propose to continue an ongoing population-based case-control study of renal cell carcinoma in Los Angeles County. The primary aims are: (1) to investigate the relationship between renal cell carcinoma and regular use of analgesics, especially those containing aspirin or other non-steroidal anti-inflammatory agents, or acetaminophen; and (2) to confirm and examine in detail our earlier findings of an association between use of diuretics and diet pills and renal cell carcinoma. The secondary aims are: (1) to further evaluate the association of renal cell carcinoma with cigarette smoking; (2) to determine whether coffee consumption is directly related to an increased risk of renal cell carcinoma; (3) to investigate the possible association between diet and renal cell carcinoma development, especially the consumption of foods rich in nitrosamines or their precursors (enhancing risk) and foods rich in vitamins A and C, and various carotenoids (reducing risk); and (4) to investigate the possible association between occupation and risk of renal cell carcinoma. All histologically confirmed cases of renal cell carcinoma diagnosed between April 1, 1986 and September 30, 1995 who are aged 25-74 years and either Black or White will be asked to participate in this study. Controls will be individually matched to the index case on race, sex, and age (within 5 years), and chosen according to a well-defined procedure from the neighborhood of the index case's residence at the time of cancer diagnosis. We expect to interview about 1280 case-control pairs of renal cell carcinoma.