ANALGESICS, DIURETICS, AND RENAL CELL CARCINOMA

镇痛药、利尿剂和肾细胞癌

• 批准号: 6236366
• 负责人: Mimi C. Yu
• 金额: $ 6.2万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6236366
• 关键词: acetaminophen; analgesics; anorexic agent; antiinflammatory agents; aspirin; caffeine; cancer registry /resource; cancer risk; coffee; diuretics; dosage; drug administration rate /duration; drug adverse effect; drug related neoplasm /cancer; human subject; iatrogenic disease; interview; longitudinal human study; medical records; neoplasm /cancer epidemiology; nutrition related neoplasm /cancer; nutrition related tag; occupational hazard; questionnaires; renal cell carcinoma; smoking; statistics /biometry

We propose to continue an ongoing population-based case-control study of renal cell carcinoma in Los Angeles County. The primary aims are: (1) to investigate the relationship between renal cell carcinoma and regular use of analgesics, especially those containing aspirin or other non-steroidal anti-inflammatory agents, or acetaminophen; and (2) to confirm and examine in detail our earlier findings of an association between use of diuretics and diet pills and renal cell carcinoma. The secondary aims are: (1) to further evaluate the association of renal cell carcinoma with cigarette smoking; (2) to determine whether coffee consumption is directly related to an increased risk of renal cell carcinoma; (3) to investigate the possible association between diet and renal cell carcinoma development, especially the consumption of foods rich in nitrosamines or their precursors (enhancing risk) and foods rich in vitamins A and C, and various carotenoids (reducing risk); and (4) to investigate the possible association between occupation and risk of renal cell carcinoma. All histologically confirmed cases of renal cell carcinoma diagnosed between April 1, 1986 and September 30, 1995 who are aged 25-74 years and either Black or White will be asked to participate in this study. Controls will be individually matched to the index case on race, sex, and age (within 5 years), and chosen according to a well-defined procedure from the neighborhood of the index case's residence at the time of cancer diagnosis. We expect to interview about 1280 case-control pairs of renal cell carcinoma.

我们建议继续进行一项以人群为基础的病例对照研究 洛杉矶县的肾细胞癌。主要目标是：(1) 探讨肾癌与常规用药的关系 止痛药，尤指含有阿司匹林或其他非类固醇的止痛药 抗炎药或对乙酰氨基酚；以及(2)确认和检查 更详细地说，我们早先发现利尿剂的使用与 减肥药和肾癌。次要目标是：(1) 进一步评价肾细胞癌与香烟的关系 吸烟；(2)确定咖啡摄入量是否与 增加患肾细胞癌的风险；(3)调查 饮食与肾癌发生的关系，尤其是 食用富含亚硝胺或其前体的食物 (增加风险)和富含维生素A和C的食物，以及各种 类胡萝卜素(降低风险)；和(4)研究可能的 职业与肾癌发病风险的相关性研究全 经组织学证实的肾细胞癌病例诊断为 1986年4月1日和1995年9月30日，年龄25-74岁 黑人或白人将被邀请参加这项研究。控制将 在种族、性别和年龄方面分别与索引案例匹配(在5岁以内 年)，并根据定义明确的程序从 在癌症诊断时，指示病例住所的邻近地区。 我们预计采访约1280对病例对照肾细胞。 癌症。