MECHANISMS OF HISTAMINE RELEASE

组胺释放机制

• 批准号: 2572227
• 负责人: R P SIRAGANIAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2572227
• 关键词: antibody receptor; basophils; biological models; biological signal transduction; calcium channel; histamine release; immunoregulation; inflammation; ionophores; leukocyte activation /transformation; mast cell; neoplastic cell culture for noncancer research; phosphorylation; protein tyrosine kinase; secretion; tissue /cell culture

Histamine release from mast cells and basophils is being studied as an immunological mechanism involved in inflammation. The activation of these cells by immune cell surface receptors is also a model for signal transduction and cell secretion. Besides cell surface receptors, the cells can be activated by other secretagogues such as the calcium ionophore A23187. The emphasis the last few years has been in understanding the role of protein tyrosine phosphorylations in the signalling. The cultured rat basophilic leukemia cells are used as one of the main models for these studies.

肥大细胞和嗜碱性粒细胞释放组胺的研究， 一种与炎症有关的免疫机制。 激活 这些细胞的免疫细胞表面受体也是一个模型， 信号转导和细胞分泌。 除了细胞表面 受体，细胞可以被其他促分泌素激活， 钙离子载体A23187。 过去几年的重点是 在了解蛋白质酪氨酸磷酸化的作用 在信号。 培养的大鼠嗜碱性白血病细胞， 作为这些研究的主要模型之一。