细胞信号转导中的蛋白质酪氨酸磷酸酶-猫眼课题宝

细胞信号转导中的蛋白质酪氨酸磷酸酶

批准号：

6161854

负责人：

R P SIRAGANIAN

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/6161854

关键词：

antibody receptor biological signal transduction cell adhesion molecules cell aggregation cellular immunity enzyme activity immunoregulation integrins phosphorylation protein structure function protein tyrosine kinase protein tyrosine phosphatase receptor expression tissue /cell culture

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中文摘要

翻译

许多细胞表面受体聚集产生酪氨酸

英文摘要

Aggregation of many cell surface receptors results in tyrosine phosphorylation of intracellular proteins. The phosphorylation state of these proteins then controls enzymatic activity and protein-protein association or dissociation thereby propagating and regulating downstream signal transduction. The level of protein phosphorylation of a molecule is due to the balance between protein tyrosine kinase and phosphatase activities. Therefore, it is important to understand the role of the protein tyrosine phosphatases in initiating, maintaining and regulating signal transduction in cells. In studies during this last year we found that the SH2 domain containing protein tyrosine phosphatase SHP-1 and SHP- 2 associate with Fc-epsilon-RI and that the SHP-2 also associates with the adhesion molecule PECAM-1 that is tyrosine phosphorylated by activation of different integrin or immune receptors.

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