IN VITRO STUDIES OF SECRETORY CELL STRUCTURE AND FUNCTION

分泌细胞结构和功能的体外研究

• 批准号: 6104558
• 负责人: R P SIRAGANIAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6104558
• 关键词: biological signal transduction; cell biology; histochemistry /cytochemistry; mast cell; receptor mediated endocytosis; secretion; structural biology; tissue /cell culture

The RBL-2H3 and other cultured cell lines are used to study various aspects of endocytic and secretory processes. Emphasis is on the use of morphological, cytochemical, biochemical characterization of cultured cells. Events involved in receptor activation and signal transduction are being investigated as well as endocytic and secretory pathways. Studies also try to investigate the cell biology of these cells, the pathways for their maturation, and development. During the last year an antibodies have been identified that bind to mast cell precursors.

使用RBL-2 H3和其它培养的细胞系 研究内吞和分泌过程的各个方面。 重点是运用形态学、细胞化学、生物化学 培养细胞的特征。受体相关事件 激活和信号转导正在研究， 内吞和分泌途径。研究也试图调查 这些细胞的细胞生物学，它们成熟的途径， 发展先行者的要求在过去的一年里， 与肥大细胞前体结合。