ALPHA-TOCOPHEROL, BETA-CAROTENE LUNG CANCER PREVENTION STUDY

α-生育酚、β-胡萝卜素预防肺癌的研究

• 批准号: 2571488
• 负责人: D ALBANES
• 金额: --
• 依托单位: DIVISION OF CANCER PREVENTION AND CONTROL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2571488
• 关键词: Scandinavian country; alcoholic beverage consumption; cancer prevention; carcinogenesis inhibitor; carotene; chemoprevention; clinical research; colon neoplasms; dietary supplements; human subject; human therapy evaluation; longitudinal human study; lung neoplasms; male; neoplasm /cancer epidemiology; neoplasm /cancer nutrition therapy; nutrition aspect of cancer; nutrition related tag; prostate neoplasms; tobacco abuse; tocopherols; vitamin therapy

Objective: The main objective of this project is to investigate whether supplementation with either vitamin E or b-carotene reduces incidence of lung and other cancers. Several hypotheses related to cancer prevention, etiology, and early detection are also being tested. Background: Abundant research indicated a role in primary cancer prevention for certain micronutrients, including vitamin E and, in particular, b-carotene, based on antioxidant and other antineoplastic properties. Methods: The ATBC Study is a randomized, placebo-controlled, double-blind, 2x2 factorial intervention trial of daily supplementation (for 5-8 years) with b-carotene (20 mg) and/or vitamin E (50 mg dl-a-tocopheryl acetate). The 29,133 participants were 50-69 year old male cigarette smokers in southwestern Finland. Serum, toenails, and questionnaire data were collected and stored at baseline, and serum, whole blood and RBC's during followup. Lung and other cancers are identified through the Finnish Cancer Registry, with central medical record and pathology reviews. Progress: Active intervention concluded in 1993, and post-trial passive followup of the cohort continues. Results of the trial showed reduced incidence in the vitamin E group for prostate (34%) and large bowel (16%) cancers. In contrast, b-carotene demonstrated no cancer preventive effects and resulted in increased cancer incidence (18% for lung cancer) and overall mortality in this study of older middle-age cigarette smokers. The possible biological interaction between b-carotene and alcohol ingestion, along with other organ-specific intervention analyses and examination of post-intervention group incidence trends are being studied. Recent etiologic analyses have shown that colon cancer risk is directly related to alcohol intake and inversely related to dietary folate, higher serum vitamin D levels are associated with reduced risk of rectal cancer, and both dietary and serum b-carotene and vitamin E levels are inversely associated with lung cancer risk. Analyses of PSA, steroid hormones, and dietary factors in relation to prostate cancer as well as several evaluations of genetic markers at different cancer sites are underway.

目的：本项目的主要目的是 研究补充维生素E 或β-胡萝卜素降低肺癌和其他癌症的发病率。 与癌症预防、病因学、 和早期检测也在测试中。 背景：大量的研究表明，在原发性 某些微量营养素的癌症预防，包括 维生素E，特别是β-胡萝卜素， 抗氧化剂和其它抗氧化性能。 方法：ATBC研究是一项随机， 安慰剂对照、双盲、2x2析因 每日补充干预试验（5-8年） 与b-胡萝卜素（20毫克）和/或维生素E（50毫克 dl-α-生育酚乙酸酯）。 29，133名参与者 美国西南部50-69岁男性吸烟者 芬兰. 血清、脚趾甲和问卷调查数据 在基线时采集并储存血清、全血 和红细胞计数 肺癌和其他癌症是 通过芬兰癌症登记处确定， 中心病历和病理学审查。 进展：1993年结束了积极干预， 继续对该队列进行试验后被动随访。 试验结果显示， 维生素E组用于前列腺（34%）和大肠（16%） 癌的 相比之下，b-胡萝卜素没有癌症 预防作用，并导致癌症增加 肺癌的发病率（18%）和总死亡率 这项针对中年吸烟者的研究。 的 β-胡萝卜素和 酒精摄入，沿着其他器官特异性 干预分析和干预后检查 正在研究群体发病率趋势。 近期病因 分析表明，结肠癌的风险直接 与酒精摄入量相关，与饮食 叶酸，较高的血清维生素D水平与 降低直肠癌的风险，饮食和血清 b-胡萝卜素和维生素E水平呈负相关 有患肺癌的风险。 前列腺特异性抗原类固醇激素， 以及饮食因素与前列腺癌的关系 作为对不同时期遗传标记的几次评估， 癌症现场正在进行中。