FINLAND STUDIES OF NUTRITION AND CANCER

芬兰的营养与癌症研究

• 批准号: 3774720
• 负责人: D ALBANES
• 金额: --
• 依托单位: DIVISION OF CANCER PREVENTION AND CONTROL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774720
• 关键词: Scandinavian country; ascorbate; breast neoplasms; caloric dietary content; cancer prevention; cancer risk; carcinogenesis inhibitor; chemoprevention; colon neoplasms; diet; dietary lipid; dietary trace element; female; human subject; lung neoplasms; neoplasm /cancer epidemiology; neoplasm /cancer nutrition therapy; nutrition related neoplasm /cancer; nutrition related tag; retinoids; selenium; tocopherols

The important relationship of diet and nutrition in the development of cancer has become well known through various research efforts. Laboratory studies have shown cancer inhibitory function for various natural and synthetic nutrients in various models, which have been corroborated by human epidemiologic studies of nutrient intake, tissue levels, and cancer incidence. The objectives of these etiologic studies are to 1) assess the role of fats; selenium; and vitamins A, E, and C in breast cancer development; and 2) evaluate the relation of intake of various nutrients to subsequent cancer, particularly breast, colon, and lung. The project includes two studies. The first is a breast cancer case-control study of fats; total calories; selenium; and vitamins A, E, and C. The role of various anthropometric measurements, genetic markers for breast cancer, and reproductive factors are being explored. The second project is a comparison of nutrient intakes in cases and reference subjects identified from an existing large cohort with prediagnostic baseline dietary histories. Associations between various dietary components and several cancers will be assessed. These studies are being conducted collaboratively with the Surveillance Program of the Division of Cancer Prevention and Control and the National Public Health Institute and Social Insurance Institute of Finland.

饮食与营养在儿童生长发育中的重要关系 通过各种研究努力，癌症已经广为人知。实验室 研究表明，多种天然和天然药物具有抗癌作用。 各种模型中的合成营养素，已得到以下证实 营养摄入、组织水平与癌症的人类流行病学研究 发病率。这些病因学研究的目的是：1)评估 脂肪、硒和维生素A、E、C在乳腺癌中的作用 以及2)评估各种营养素的摄入量与 继发性癌症，特别是乳腺癌、结肠癌和肺癌。该项目 包括两项研究。第一项是关于乳腺癌的病例对照研究。 脂肪；总卡路里；硒；维生素A、E和C。 各种人体测量，乳腺癌的遗传标记，以及 人们正在探索生殖因素。第二个项目是一个 确定的病例和参考对象的营养素摄入量的比较 来自现有的具有诊断前基线饮食的大型队列 历史。不同的饮食成分与几种 将对癌症进行评估。 这些研究是与监督组织合作进行的 癌症预防与控制司和国家癌症预防控制中心 芬兰公共卫生研究所和社会保险研究所。