FELS EARLY NUTRITION, GROWTH, & BREAST CANCER RISK FACTO

目的：该项目调查了儿童营养与乳腺癌风险因素之间的关系，包括初潮年龄，成年身高，体重和肥胖。次要目标包括跟踪从出生到青年期肥胖的发展，以确定饮食对儿童和成人肥胖发展的贡献，并探讨回顾性儿童饮食评估的可行性。背景：初潮年龄早、肥胖、体重增加和身高与乳腺癌和其他癌症的风险增加有关。在儿童和成年期，热量摄入超过需要量被认为是肥胖的主要原因，并被认为有助于下丘脑-性腺成熟和初潮的时间，以及任何给定的身高遗传倾向的更大的身高。关键时期和高风险饮食的识别将有助于乳腺癌的预防策略。方法：连续儿童饮食日记记录，人体测量数据（包括身高，体重，皮褶厚度）和人口统计学特征，可从费尔斯研究人类生物学系的赖特州立医学院检索106名女性参与者。可评估的营养素包括总能量、脂肪、蛋白质和碳水化合物、饱和脂肪、多不饱和脂肪和单不饱和脂肪;胆固醇;膳食纤维;以及维生素和矿物质（来自食物和补充来源）。 进展：对106名女孩的饮食数据进行了编码，并将其与人体测量数据（儿童期至成年期）和月经初潮数据联系起来。分析显示了食物摄入量随生长和发育的预期趋势（例如，随着年龄的增长增加能量、蛋白质和脂肪的摄入）。初潮年龄与儿童时期的能量和绝对脂肪摄入量呈负相关，但与来自脂肪的卡路里百分比无关。饮食和人体测量（包括肥胖）之间的相互关系，在不同年龄和初潮年龄将进行详细分析。一个由35名女孩组成的子样本，现在已经成年，完成了两份食物频率问卷，询问她们在高中期间的饮食摄入情况，这些数据将与她们的青少年饮食进行比较，以评估这种远程回忆的可行性。

OBJECTIVE: This project investigates the relationship between childhood nutrition and breast cancer risk factors, including age at menarche, adult height, weight, and fatness. Secondary objectives include tracking the development of obesity from birth through young adulthood, to identify the contribution of diet to the development of childhood and adult obesity, and to explore the feasibility of retrospective childhood dietary assessment. Background: Early age at menarche, as well as obesity, weight gain, and tallness are associated with increased risk of breast and other cancers. Caloric intake in excess of requirements during childhood and adulthood is considered the primary cause of obesity, and believed to contribute to the timing of hypothalamic-gonadal maturation and menarche and to greater body height for any given hereditary predisposition of stature. Identification of critical periods and high-risk diets would be useful to breast cancer prevention strategies. METHODS: Serial childhood dietary diary records, anthropometric data (including height, weight, skinfold thickness) and demographic characteristics available from the Fels Study within the Division of Human Biology of the Wright State School of Medicine were retrieved for 106 female participants. Evaluable nutrients include total energy, fat, protein, and carbohydrate, saturated, polyunsaturated, and monounsaturated fat; cholesterol; dietary fiber; and vitamins and minerals (from food and supplementary sources). PROGRESS: Dietary data have been coded and linked with the anthropometric (childhood through adulthood) and menarche data for the 106 girls. Analysis shows the expected trends in food intake with growth and development (e.g., increasing energy, protein, and fat intake with age). Age at menarche is inversely associated with both energy and absolute fat intake in childhood, but not with percent of calories from fat. The interrelationships between diet and anthropometry (including obesity) at various ages and age at menarche will be analyzed in detail. A subsample of 35 girls, now adults, completed two food frequency questionnaires that asked about their dietary intake during high school, and these data will be compared to their adolescent diets to assess the feasibility of such remote recall.