Age-related mechanisms of amino acid signalling in skeletal muscle

骨骼肌氨基酸信号传导的年龄相关机制

• 批准号: DP190101937
• 负责人: Prof Gordon Lynch
• 金额: $ 35.04万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-02-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101937
• 关键词: Age; related; mechanisms; amino; acid

This project aims to increase our understanding of the role of glycine receptor-mediated signalling and its metabolism in the amino acid sensing capacity of mTORC1, a key enzyme regulating muscle protein synthesis. Ageing is associated with a progressive decline in skeletal muscle mass, weakness, and impaired regeneration after injury. Impaired anabolic signalling after food intake has been proposed as a key contributor, yet the metabolic pathways responsible for nutrient sensing and regulation of protein synthesis remain unresolved. The project will assess defective amino acid sensing and protein synthesis in old mammals, identifying the role of glycine signalling in these processes. The project expects to underpin development of muscle-specific modulators of muscle homeostasis with broad relevance to Australia’s ageing population.

该项目旨在增加我们对甘氨酸受体介导的信号传导及其代谢在mTORC 1的氨基酸传感能力中的作用的理解，mTORC 1是调节肌肉蛋白质合成的关键酶。摄入食物后合成代谢信号受损已被认为是一个关键因素，但负责营养感测和蛋白质合成调控的代谢途径仍未得到解决。该项目将评估老年哺乳动物中有缺陷的氨基酸传感和蛋白质合成，确定甘氨酸信号在这些过程中的作用。该项目预计将支持肌肉稳态的肌肉特异性调节剂的发展，与澳大利亚的老龄化人口具有广泛的相关性。