Heat shock protein therapy for muscle wasting

热休克蛋白疗法治疗肌肉萎缩

• 批准号: nhmrc : GNT1065456
• 负责人: Prof Gordon Lynch
• 金额: $ 111.37万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/heat-shock-protein-muscle-wasting/1344885
• 关键词: Heat; shock; protein; therapy; muscle

Heat shock proteins help stressed proteins fold back to their original conformation and restore function. In a discovery published in Nature we identified induction of heat shock protein 72 (Hsp72) as a novel approach for muscular dystrophy and other conditions where there is inflammation and muscle weakness. This proposal will investigate whether Hsp72 induction is similarly effective in tackling the muscle wasting and weakness in conditions like ageing and frailty and in muscle injury.

热休克蛋白帮助应激蛋白折叠回原来的构象，恢复功能。在《自然》杂志上发表的一项发现中，我们发现热休克蛋白72 （Hsp72）的诱导是一种治疗肌肉萎缩症和其他炎症和肌肉无力的新方法。该提案将调查Hsp72诱导是否同样有效地解决肌肉萎缩和虚弱的条件，如衰老和虚弱和肌肉损伤。