Modulating heat shock protein expression in skeletal muscle to improve the pathophysiology of muscular dystrophy

调节骨骼肌中的热休克蛋白表达以改善肌营养不良症的病理生理学

• 批准号: nhmrc : 1009114
• 负责人: Prof Gordon Lynch
• 金额: $ 33.5万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulating-heat-shock-muscular-dystrophy/109373
• 关键词: Modulating; heat; shock; protein; expression

Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy. Dystrophic muscles are fragile, prone to injury, and regenerate poorly after damage. Defective calcium handling has been implicated in these processes. We have revealed that upregulating levels of stress proteins called _heat shock proteins� (HSPs) can improve calcium regulation in muscular dystrophy. Modulating the HSP response has significant potential to delay the onset or slow the progression of DMD.

杜氏肌营养不良症（DMD）是最常见和最严重的形式的肌营养不良症。营养不良的肌肉是脆弱的，容易受伤，损伤后再生不良。这些工艺中涉及钙处理缺陷。我们已经发现，上调称为热休克蛋白（HSP）的应激蛋白水平可以改善肌营养不良症中的钙调节。调节HSP反应具有延迟DMD发作或减缓DMD进展的显著潜力。