Modulating heat shock protein expression in skeletal muscle to improve the pathophysiology of muscular dystrophy
Modulating heat shock protein expression in skeletal muscle to improve the pathophysiology of muscular dystrophy
批准号:
nhmrc : 1009114
负责人:
Prof Gordon Lynch
金额:
$33.5万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2014-12-31
中文摘要
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英文摘要
Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy. Dystrophic muscles are fragile, prone to injury, and regenerate poorly after damage. Defective calcium handling has been implicated in these processes. We have revealed that upregulating levels of stress proteins called _heat shock proteins� (HSPs) can improve calcium regulation in muscular dystrophy. Modulating the HSP response has significant potential to delay the onset or slow the progression of DMD.
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财政年份:2017
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依托单位:
Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy
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资助金额:$53.33万
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财政年份:2017
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Understanding the cellular cues that direct muscle stem cell specification
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财政年份:2015
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依托单位:
Therapeutic potential of modulating heat shock protein expression for muscle wasting disorder
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批准号:nhmrc : 1065456
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项目类别:Project Grants
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资助金额:$78.16万
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财政年份:2014
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负责人:Prof Gordon Lynch
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依托单位:
Heat shock protein therapy for muscle wasting
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批准号:nhmrc : GNT1065456
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项目类别:Project Grants
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资助金额:$111.37万
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财政年份:2014
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负责人:Prof Gordon Lynch
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依托单位:
Role of suppressor of cytokine signalling proteins (SOCS3) in defective muscle repair and ageing
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批准号:DP120101494
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资助金额:$21.48万
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财政年份:2012
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负责人:Prof Gordon Lynch
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依托单位:
Regulating calcium handling in skeletal muscle - implications for muscle contraction, injury and repair, ageing and development
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批准号:DP0772781
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项目类别:Discovery Projects
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资助金额:$20.16万
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财政年份:2008
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负责人:Prof Gordon Lynch
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依托单位:
Modulating the molecular and cellular physiology of ageing skeletal muscle
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依托单位:
Targeting calcineurin for improving muscle regeneration in skeletal muscle disease
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项目类别:NHMRC Project Grants
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资助金额:$20.2万
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财政年份:2005
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负责人:Prof Gordon Lynch
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依托单位:
THE ROLE OF INTRACELLULAR CALCIUM IN THE MECHANISMS OF INJURY, REGENERATION AND PLASTICITY OF SKELETAL MUSCLE
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批准号:nhmrc : 990801
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项目类别:NHMRC Project Grants
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资助金额:$14.43万
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财政年份:1999
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负责人:Prof Gordon Lynch
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依托单位:
国内基金
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