Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy
Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy
批准号:
nhmrc : GNT1124474
负责人:
Prof Gordon Lynch
金额:
$78.05万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 --
中文摘要
点击翻译按钮获取中文摘要
英文摘要
There is no cure for DMD, a devastating, life-limiting muscle disease causing progressive muscle wasting in boys and young men. A potential therapy may come from modulating muscle activity patterns to promote a protective slow muscle phenotype through low-frequency stimulation protocols and/or well-described pharmacological ‘exercise mimetics’. This proposal will evaluate their therapeutic merit in mouse models of DMD to answer the key questions to advance this approach to the clinic.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Interrogating the extremes of skeletal muscle plasticity in vertebrates
-
批准号:DP240102721
-
项目类别:Discovery Projects
-
资助金额:$35.6万
-
财政年份:2024
-
负责人:Prof Gordon Lynch
-
依托单位:
Age-related mechanisms of amino acid signalling in skeletal muscle
-
批准号:DP190101937
-
项目类别:Discovery Projects
-
资助金额:$35.04万
-
财政年份:2019
-
负责人:Prof Gordon Lynch
-
依托单位:
Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy
-
批准号:nhmrc : 1124474
-
项目类别:Project Grants
-
资助金额:$53.33万
-
财政年份:2017
-
负责人:Prof Gordon Lynch
-
依托单位:
Understanding the cellular cues that direct muscle stem cell specification
-
批准号:DP150100206
-
项目类别:Discovery Projects
-
资助金额:$51.53万
-
财政年份:2015
-
负责人:Prof Gordon Lynch
-
依托单位:
Therapeutic potential of modulating heat shock protein expression for muscle wasting disorder
-
批准号:nhmrc : 1065456
-
项目类别:Project Grants
-
资助金额:$78.16万
-
财政年份:2014
-
负责人:Prof Gordon Lynch
-
依托单位:
Heat shock protein therapy for muscle wasting
-
批准号:nhmrc : GNT1065456
-
项目类别:Project Grants
-
资助金额:$111.37万
-
财政年份:2014
-
负责人:Prof Gordon Lynch
-
依托单位:
Role of suppressor of cytokine signalling proteins (SOCS3) in defective muscle repair and ageing
-
批准号:DP120101494
-
项目类别:Discovery Projects
-
资助金额:$21.48万
-
财政年份:2012
-
负责人:Prof Gordon Lynch
-
依托单位:
Modulating heat shock protein expression in skeletal muscle to improve the pathophysiology of muscular dystrophy
-
批准号:nhmrc : 1009114
-
项目类别:NHMRC Project Grants
-
资助金额:$33.5万
-
财政年份:2011
-
负责人:Prof Gordon Lynch
-
依托单位:
Regulating calcium handling in skeletal muscle - implications for muscle contraction, injury and repair, ageing and development
-
批准号:DP0772781
-
项目类别:Discovery Projects
-
资助金额:$20.16万
-
财政年份:2008
-
负责人:Prof Gordon Lynch
-
依托单位:
Modulating the molecular and cellular physiology of ageing skeletal muscle
-
批准号:DP0665071
-
项目类别:Discovery Projects
-
资助金额:$17.94万
-
财政年份:2006
-
负责人:Prof Gordon Lynch
-
依托单位:
Targeting calcineurin for improving muscle regeneration in skeletal muscle disease
-
批准号:nhmrc : 350439
-
项目类别:NHMRC Project Grants
-
资助金额:$20.2万
-
财政年份:2005
-
负责人:Prof Gordon Lynch
-
依托单位:
THE ROLE OF INTRACELLULAR CALCIUM IN THE MECHANISMS OF INJURY, REGENERATION AND PLASTICITY OF SKELETAL MUSCLE
-
批准号:nhmrc : 990801
-
项目类别:NHMRC Project Grants
-
资助金额:$14.43万
-
财政年份:1999
-
负责人:Prof Gordon Lynch
-
依托单位:
国内基金
海外基金
登录
查看更多内容
TRPV1受体在盐敏感性高血压过程中所介导的肾脏保护作用的机理研究
-
批准号:81170243
-
项目类别:面上项目
-
资助金额:60.0万元
-
批准年份:2011
-
负责人:王幼平
-
依托单位:
气体信号分子硫化氢对颈动脉窦压力反射感受器的调节作用及机制
-
批准号:81100181
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2011
-
负责人:廖莹
-
依托单位:
HCN4在心房颤动肺静脉电位形成中作用的研究
-
批准号:81000082
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2010
-
负责人:王新华
-
依托单位:
Transient Receptor Potential 通道 A1在膀胱过度活动症发病机制中的作用
-
批准号:30801141
-
项目类别:青年科学基金项目
-
资助金额:28.0万元
-
批准年份:2008
-
负责人:都书琪
-
依托单位:
感觉神经递质CGRP通过与P物质的相互作用改善心肌缺血的机制探讨
-
批准号:30801213
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2008
-
负责人:王利宏
-
依托单位:
人脐血间充质干细胞成骨潜能亚群的特异性分子标志
-
批准号:30800232
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2008
-
负责人:刘广鹏
-
依托单位:
脂肪干细胞软骨潜能亚群的特异性分子标志
-
批准号:30772264
-
项目类别:面上项目
-
资助金额:28.0万元
-
批准年份:2007
-
负责人:周广东
-
依托单位: