Therapeutic potential of modulating heat shock protein expression for muscle wasting disorder

调节热休克蛋白表达对肌肉萎缩症的治疗潜力

• 批准号: nhmrc : 1065456
• 负责人: Prof Gordon Lynch
• 金额: $ 78.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/therapeutic-potential-modulating-wasting-disorder/455170
• 关键词: Therapeutic; potential; modulating; heat; shock

Heat shock proteins help stressed proteins fold back to their original conformation and restore function. In a discovery published in Nature we identified induction of heat shock protein 72 (Hsp72) as a novel approach for muscular dystrophy and other conditions where there is inflammation and muscle weakness. This proposal will investigate whether Hsp72 induction is similarly effective in tackling the muscle wasting and weakness in conditions like ageing and frailty and in muscle injury.

热休克蛋白帮助应激蛋白折叠回其原始构象并恢复功能。在发表在《自然》杂志上的一项发现中，我们将热休克蛋白72（Hsp72）的诱导确定为肌营养不良症和其他炎症和肌肉无力疾病的新方法。该提案将研究Hsp72诱导是否同样有效地解决衰老和虚弱以及肌肉损伤等情况下的肌肉萎缩和虚弱。