Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy

骨骼肌可塑性和慢肌编程对肌营养不良症的治疗潜力

• 批准号: nhmrc : 1124474
• 负责人: Prof Gordon Lynch
• 金额: $ 53.33万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/therapeutic-potential-skeletal-muscular-dystrophy/947365
• 关键词: Therapeutic; potential; skeletal; muscle; plasticity

There is no cure for DMD, a devastating, life-limiting muscle disease causing progressive muscle wasting in boys and young men. A potential therapy may come from modulating muscle activity patterns to promote a protective slow muscle phenotype through low-frequency stimulation protocols and/or well-described pharmacological ‘exercise mimetics’. This proposal will evaluate their therapeutic merit in mouse models of DMD to answer the key questions to advance this approach to the clinic.

DMD是一种毁灭性的、限制生命的肌肉疾病，导致男孩和年轻男性的肌肉进行性萎缩，目前尚无治愈方法。一种潜在的治疗方法可能来自调节肌肉活动模式，通过低频刺激方案和/或描述良好的药理学“运动模拟物”来促进保护性缓慢肌肉表型。本提案将评估它们在DMD小鼠模型中的治疗价值，以回答将该方法推向临床的关键问题。