Regulating calcium handling in skeletal muscle - implications for muscle contraction, injury and repair, ageing and development

了解骨骼肌中钙的调节机制对于研究肌肉生长和发育、损伤和修复以及确定衰老相关疾病、重建手术、运动和工作场所损伤以及肌肉疾病的治疗靶点和潜在疗法具有重要意义。结合细胞生理学、荧光显微镜和数字成像技术研究骨骼肌等多细胞组织，将增强澳大利亚生物研究的国际竞争力。该研究将优化基因递送系统的开发，该系统可能最终应用于肌肉萎缩性疾病和肌肉无力影响生活质量的疾病。

Understanding the mechanisms regulating calcium in skeletal muscle has important relevance for studying muscle growth and development, injury and repair, and for identifying therapeutic targets and potential therapies for ageing-related disorders, reconstructive surgery, sporting and workplace injuries, and muscle diseases. Combining cell physiology, fluorescence microscopy and digital imaging technologies for studying multicellular tissues such as skeletal muscle will enhance the international competitiveness of Australian biological research. The research will optimise development of gene delivery systems that may find eventual application for muscle wasting disorders and conditions where muscle weakness compromises quality of life.