SUSPECTED INFLUENCES ON METHAMPHETAMINE USE

这是一份B/START提案，来自一位寻求试点研究的新研究者 关于甲基安非他明的数据，这是联合国若干区域日益严重的问题， 美国，特别是关岛。 拟议 试点研究将建立在现有的关系， 过去两年来国际和平组织与关岛政府 精神健康和药物滥用 这项B/START试点研究将 为作为新研究者的PI提供初步试验的机会 社区和临床确定的抽样方法 甲基苯丙胺使用者将为更大的流行病奠定基础 调查事务所 此外，两类风险因素将被 假设与甲基苯丙胺用途：相关的研究： 1)以前的药物参与;特别是假设， 酗酒和大麻使用史将预示着 使用甲基苯丙胺的风险; 2）家庭影响;它是 假设甲基苯丙胺和其他毒品的使用集中在 家庭，并与一些家庭特征相关联， 包括文化身份的丧失。 最后，本研究将研究 怀疑从吸食冰毒转变为注射甲基苯丙胺， 从病例的临床样本中收集证据， 流行病学样本 这项研究的最终目标是， 从这个小的试点研究开始，将填补我们在 了解毒品参与的顺序， 甲基苯丙胺依赖，以及指向潜在的可塑性 危险因素 这些信息不仅对药物有价值， 关岛的预防计划规划者和治疗提供者， 可能是面临类似的甲基苯丙胺使用爆发的个人 在夏威夷和美国本土。

This is a B/START proposal from a new investigator seeking pilot study data on methamphetamine, a growing problem in several regions of the United States, and in particular, the Territory of Guam. The proposed pilot study will build on the existing relationship established over the past two years between the PI and the Government of Guam's Department of Mental Health and Substance Abuse. This B/START pilot study will provide the opportunity for the PI as a new investigator to pilot test methods for sampling community and clinically-ascertained methamphetamine users that will set the stage for larger epidemiologic investigations. In addition, two classes of risk factors will be studied that are hypothesized to be associated with methamphetamine use: 1) previous drug involvement; specifically it is hypothesized that a history of heavy alcohol and marijuana use will signal an increase in the risk for methamphetamine use; and 2) familial influences; it is hypothesized that methamphetamine and other drug use is clustered within families and associated with a number of family characteristics, including loss of cultural identity. Lastly, this study will study the suspected transition from ice smoking to injecting methamphetamine, gathering evidence from both the clinical sample of cases, and the epidemiologic sample. The ultimate goal of this line of research, starting with this small pilot study, will be to fill gaps in our understanding of the sequencing of drug involvement leading up to methamphetamine dependence, as well as point to potentially malleable risk factors. This information will be valuable not only to drug prevention program planners and treatment providers on Guam, but also possibly to individuals facing similar outbreaks of methamphetamine use on Hawaii and the U.S. mainland.