Scientific Core

科学核心

• 批准号: 7813638
• 负责人: AMELIA M ARRIA
• 金额: $ 55.03万
• 依托单位: TREATMENT RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7813638
• 关键词: Americas; Center for Translational Science Activities; Charge; Clinical Trials Data Monitoring Committees; Collaborations; Communication; Communication Research; Confidentiality of Patient Information; Data; Decision Making; Environment; Fostering; Generic Drugs; Goals; Intervention; Interviewer; Knowledge; Mentors; Methods; Monitor; Parents; Participant; Pennsylvania; Pharmaceutical Preparations; Pilot Projects; Procedures; Process; Public Health; Publications; Research; Research Ethics; Research Ethics Committees; Research Institute; Research Personnel; Research Project Grants; Resources; Safety; Scientist; Services; Structure; Training; Translating; Universities; Work; addiction; adolescent substance abuse; career; data integrity; data management; data sharing; design; evidence base; follow-up; operation; tool

The Scientific Core of the proposed Parents' Translational Research Center will coordinate the research needs ofthe three Core projects and pilot studies. The overall aims ofthe Scientific Core are to: 1) Manage the collecfion, processing, analysis and publication of data emanating from the studies in an efficient manner; 2) Maintain the highest level of research ethics, data integrity and methodological standards for all activities; and 3) Incorporate communications expertise to translate our findings into useful, evidence-based tools for parents and other consumers. Within the Core, the day-to-day management ofthe research, communication, training and mentoring functions will be served by a weekly Center Management Team consisting of Drs. McLellan (Center Director), Winters (Associate Center Director), Arria (Scientific Director), Ms. Faranda Diedrich (Coordinator); and Mr. Pasierb (CEO, The Partnership for Drug Free America). The Center Management Team will facilitate planning, coordinafion, and Implementafion of the research projects, plan analyses and promote collaboration. This core will use the existing Data Management Unit, as well as the IRB and Data Safety and Monitoring Board (DSMB) already funcfioning within the Treatment Research Institute (TRI). The Scientific Core will provide important core services to all projects and investigators (Scientific Decision Making, Scientific Review and Guidance, Study Coordination, Data Management, and Data Sharing with Other Centers). Initial training of all research assistants, coordinators and investigators will be a key responsibility of the Scientific Core, providing standardized, center-wide training in four generic research procedures necessary for efficient operation of all Center studies (interviewer training, participant recruitment, assurance of participant safety and confidentiality, and patient tracking and follow-up). Mentoring of New Investigators will be managed by a specially appointed Director of Training and Mentoring (Dr. Kirby) who will be charged with monitoring and fostering the developing careers of fellows and new scientists within the Center. Finally, the Scientific Core (with its Advisory Boards) will be responsible for selecting and managing two pilot projects each year, using a review process that encourages work by New Investigators.

拟建的家长翻译研究中心的科学核心将协调 三个核心项目的研究需求和试点研究。科学核心的总体目标是： 1)管理研究产生的数据的收集、处理、分析和发布 高效的工作方式； 2)为所有人维持最高水平的研究道德、数据完整性和方法标准 活动；以及 3)整合通信专业知识，将我们的调查结果转化为有用的、基于证据的工具 父母和其他消费者。 在核心内部，对研究、沟通、培训和 指导职能将由McLellan博士组成的每周中心管理团队提供 (中心主任)、温特斯(副中心主任)、阿里亚(科学主任)、Faranda Diedrich女士 (协调员)和Pasierb先生(美洲无毒品伙伴关系首席执行官)。中心管理 团队将促进研究项目的计划、协调和实施，计划分析和 促进协作。这一核心将使用现有的数据管理股以及内部审查委员会和数据 已经在治疗研究所(TRI)内运作的安全和监测委员会(DSMB)。 科学核心将为所有项目和调查人员提供重要的核心服务(科学 决策、科学审查和指导、研究协调、数据管理和数据共享 与其他中心合作)。对所有研究助理、协调员和调查人员进行初步培训将是关键 科学核心的职责是在中心范围内提供标准化的培训，提供有效运作所有中心研究所必需的四种通用研究程序(面试者培训、参与者招募、参与者安全和机密性保证以及患者跟踪和后续行动)。 新调查人员的指导将由一名特别任命的培训和指导主任(柯比博士)管理，他将负责监督和促进中心内研究员和新科学家的职业发展。 最后，科学核心(及其咨询委员会)将负责每年选择和管理两个试点项目，采用鼓励新调查人员开展工作的审查程序。