HEARING IMPAIRMENT AND CMV INFECTION IN YOUNG CHILDREN

该项目的主要目标是确定流行率和 感音神经性听力进行性和/或延迟性发作的年龄 丢失(SNHL)最有可能发生在婴幼儿中，原因是 先天性巨细胞病毒(CMV)感染。我们的项目还将定义 新生儿期危险因素对CMV感染者SNHL的预测作用 临床上没有明显疾病的婴儿。我们的第三个目标将定义 巨细胞病毒感染对迟发性耳聋的相对贡献 人口数量。这些目标将通过识别所有新生儿来实现 来自大学医院的先天性巨细胞病毒感染并连续 测试他们，以评估他们在不同年龄的听力敏感度。另外， 随机选择两组CMV阴性和 通过新生儿听力筛查，其中一个来自基于风险标准的筛查 另一位来自Well婴儿托儿所，将被跟踪和比较 CMV阳性儿童出生时无听力损失。所有出生的婴儿 目前在大学医院进行了先天性病毒筛查 CMV感染的调查人员提出了这一建议。在3周，3周，6周， 在12个月大的时候，每个CMV阳性的婴儿都会有一个完整的 由临床听力专家进行的听力学评估，将包括 听性脑干诱发反应(ABR)及其导抗测量 耳朵。此外，每个孩子在18岁时都将接受完整的听力评估， 24个月和30个月龄，包括行为测听 评估(视觉增强或玩耍测听)和导纳 获得纯音阈值、语音接收阈值和 言语辨别分数。控制组将得到类似的 在6个月、12个月和18个月时进行听力学评估。我们的建议将 提供有关SNHL流行病学和自然病史的更多知识 由于巨细胞病毒。这些信息对于计划及早发现和 婴幼儿SNHL的干预策略。

The primary objective of this project is to determine the prevalence and the ages when progressive and/or delayed onset of sensorineural hearing loss (SNHL) is most likely to occur in infants and young children due to congenital cytomegalovirus (CMV) infection. Our project will also define risk factors in the newborn period that predict SNHL in CMV infected infants without clinically apparent disease. Our third aim will define the relative contribution of CMV infection to delayed onset hearing loss in the population. These aims will be achieved by identifying all newborns with congenital CMV infection from University Hospital and serially testing them to evaluate their hearing sensitivity at various ages. Also, two randomly selected control groups of newborns who are CMV negative and pass a newborn auditory screen, one from the risk criteria based screening and the other from the well baby nurseries, will be followed and compared to CMV positive children without hearing loss at birth. All infants born at University Hospital are currently screened virologically for congenital CMV infection by the investigators of this proposal. At 3 weeks, 3, 6, and 12 months of age, each CMV positive infant will have a complete audiological evaluation by a clinical audiologist that will include an auditory brainstem evoked response (ABR) and immittance measures for each ear. Also, each child will have a complete audiological evaluation at 18, 24 and 30 months of age that will include behavioral audiometric assessment (visual reinforcement or play audiometry) and immittance measures to obtain pure tone thresholds, speech reception thresholds and speech discrimination scores. The control groups will receive similar audiological evaluations at 6, 12, and 18 months of age. Our proposal will provide better knowledge of the epidemiology and natural history of SNHL due to CMV. This information is essential for planning early detection and intervention strategies for SNHL in infants and young children.