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THREE DIMENSIONAL ORGANIZATION OF THE OCULOMOTOR SYSTEM

动眼系统的三维组织

基本信息

批准号：
2838352
负责人：
Dora Angelaki
金额：
$ 6.18万
依托单位：
UNIVERSITY OF MISSISSIPPI MED CTR
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-12-01 至 1999-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2838352
关键词：
Macaca fascicularis brain electrical activity electrical measurement eye movements head movements motion perception neural information processing neuroanatomy vestibular nuclei vestibular pathway visual pathways visual photosensitivity visual stimulus

项目摘要

The vestibulo-ocular system serves to maintain gaze stability during head movements. Trauma to the system, or disease states such as gaze palsies or ophthalmoplegia can produce oculomotor deficits that are disorienting and sometimes difficult to resolve clinically. In order to provide more effective treatments for oculomotor and vestibular disturbances, a more thorough scientific understanding of the function of these brain systems must be acquired. Signals from the vestibular labyrinths converge with visual inputs in a region of the brainstem that comprise the vestibular nuclei. Most previous investigations attempting to elucidate the exact role of vestibular nuclei neurons in vestibulo-ocular computations have been limited to examining neural responses that are associated with only horizontal or vertical eye movements. Movement of the eyes and head, however, have three degrees of freedom. In order to understand the sensory-to-motor transformations that control ocular motility, an examination of the neural coding in motor and premotor structures that produces three-dimensional eye movements is necessary. The proposed study will, for the first time, examine the three-dimensional organization of the response properties of vestibular nuclei neurons during spontaneous and visually-evoked eye movements, as well as during head rotation and linear translation. Binocular three-dimensional eye movements will be monitored and correlated with the neuronal discharge. Electrical stimulation will be used to identify vestibular nuclei neurons in terms of their labyrinthine inputs as well as their outputs to abducens, trochlear or oculomotor nuclei. The proposed experiments have two main aims. First to investigate the three-dimensional organization of eye position and eye angular velocity signals in oculomotor related vestibular nuclei cells. Second, to quantitatively evaluate the three-dimensional spatio-temporal organization of head motion signals in these neurons during angular rotation and linear translation. The relationship between the spatial organization of oculomotor and vestibular signals will also be delineated. Electrophysiological studies and theoretical modeling will both be utilized to achieve the specific aims of the proposed project. These results will provide a better understanding of the sensory-to-motor transformations that occur in the vestibulo-ocular system for the control of eye movements that direct vision in a three-dimensional world.

前庭-眼系统用于在头部运动期间维持凝视稳定性，动作系统创伤或疾病状态，如凝视麻痹或眼肌麻痹可产生使人迷失方向的眼球缺陷，有时很难在临床上解决。为了提供更多有效的治疗眼病和前庭障碍，更对这些大脑系统功能的全面科学理解必须获得。来自前庭神经束的信号视觉输入在脑干的区域，包括前庭原子核。大多数以前的调查试图阐明确切的前庭核神经元在前庭眼计算中的作用仅限于检查仅与水平或垂直的眼球运动。眼睛和头部的运动，然而具有三个自由度。为了解控制眼球运动的感觉到运动的转换，检查运动和前运动结构中的神经编码，产生三维眼球运动是必要的。拟定研究第一次，我们将研究三维组织，前庭神经核神经元自发放电时的反应特性和视觉诱发的眼球运动，以及在头部旋转，线性平移双目三维眼球运动将是监测并与神经元放电相关联。电刺激将被用来识别前庭核神经元的条款，它们的外展输入和外展输出或眼神经核。拟议的实验有两个主要目的。第一研究眼位和眼位的三维结构，眼相关前庭核细胞角速度信号。第二，定量评价三维时空在这些神经元中的头部运动信号的组织在角运动期间旋转和线性平移。空间关系还将描绘眼和前庭信号的组织。电生理学研究和理论建模都将是用于实现拟议项目的具体目标。这些结果将提供一个更好的理解的感觉到运动在前庭-眼系统中发生的用于控制在三维世界中引导视觉的眼球运动。

项目成果

期刊论文数量（27）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Primate translational vestibuloocular reflexes. IV. Changes after unilateral labyrinthectomy.

灵长类动物平移前庭眼反射。

DOI：
10.1152/jn.2000.83.5.3005
发表时间：
2000
期刊：
Journal of neurophysiology
影响因子：
2.5
作者：
Angelaki,DE;Newlands,SD;Dickman,JD
通讯作者：
Dickman,JD

Kinematic principles of primate rotational vestibulo-ocular reflex. I. Spatial organization of fast phase velocity axes.

灵长类动物旋转前庭眼反射的运动学原理。

DOI：
10.1152/jn.1997.78.4.2193
发表时间：
1997
期刊：
Journal of neurophysiology.
影响因子：
0
作者：
Hess,BJ;Angelaki,DE
通讯作者：
Angelaki,DE

Primate translational vestibuloocular reflexes. III. Effects of bilateral labyrinthine electrical stimulation.

灵长类动物平移前庭眼反射。

DOI：
10.1152/jn.2000.83.3.1662
发表时间：
2000
期刊：
Journal of neurophysiology.
影响因子：
0
作者：
Angelaki,DE;McHenry,MQ;Dickman,JD;Perachio,AA
通讯作者：
Perachio,AA

Differential processing of semicircular canal signals in the vestibulo-ocular reflex.

前庭眼反射中半规管信号的微分处理。

DOI：
10.1523/jneurosci.15-11-07201.1995
发表时间：
1995
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience.
影响因子：
0
作者：
Angelaki,DE;Hess,BJ;Suzuki,J
通讯作者：
Suzuki,J

Inertial processing of vestibulo-ocular signals.

前庭眼信号的惯性处理。