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MECHANISMS OF NEGLECT DYSLEXIA

忽视阅读障碍的机制

基本信息

批准号：
2891978
负责人：
ALFONSO CARAMAZZA
金额：
$ 31.41万
依托单位：
HARVARD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-09-10 至 2000-07-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2891978
关键词：
attention brain disorders brain mapping cerebral dominance clinical research cognition disease /disorder classification dyslexia human subject neural information processing neuropsychological tests neuropsychology visual perception

项目摘要

The goal of the proposed research is to understand the bases of various forms of dyslexia resulting from damage to the early stages of visual work recognition. Of particular interest is neglect dyslexia--those impairments of reading which disproportionately affect the side of words contralateral to the side of brain damage (either the right or the left hemisphere). The principal aims of the research are 1) to characterize the various forms of neglect and other peripheral dyslexias in terms of damage to the perceptual, attentional and cognitive/linguistic mechanisms that underlie visual word recognition and reading and 2) to specify neuroanatomical correlates of the different forms of the deficit. As part of this effort we will evaluate a set of hypotheses about the representation and processing of spatial structure by the normal visual word recognition system, and how selective damage to parts of this complex process can result in the observed forms of neglect and other peripheral dyslexias. To address these issues, we propose to carry out a two-phase program of research. Phase I will consist in the administration of an extensive battery of tests to brain-damaged patients with clinical signs of unilateral visual neglect in reading or other tasks (e.g. line cancellation) and patients with other forms of peripheral dyslexia; Phase II will consist in the highly detailed investigation of individual patients who present with relatively selective deficits of the various levels of processing in the early stages of visual word recognition. Phase I will serve as the basis for an initial "classification " of patients into subtypes corresponding to the forms of neglect dyslexia or other peripheral dyslexias predicted by the multi-stage model of visual word recognition. Phase II will serve as the basis for testing specific hypotheses regarding the attentional, perceptual, and cognitive/linguistic components operating at different levels of representation. The results of both phases will be used to explore hypotheses about the neuroanatomical correlates of the different subtypes of neglect dyslexia and of the processing mechanisms that are implicated in these forms of neglect. In short, the proposed investigation should provide important evidence for our understanding of: 1) the clinical manifestations of various forms of neglect and other peripheral dyslexias; 2) the nature and organization of perceptual, attentional and cognitive/linguistic processes in normal reading; 3) the possible neuroanatomical correlates for the hypothesized components of the visual word recognition system; and 4) the relationship between various forms of neglect dyslexia and the more general disorder of unilateral spatial neglect.

拟议研究的目标是了解各种由于视觉工作的早期阶段受到损害而导致的各种形式的阅读障碍识别. 特别有趣的是忽视型阅读障碍--这些缺陷阅读不成比例地影响对侧的单词脑损伤的一侧（右半球或左半球）。的研究的主要目的是1）描述各种形式的忽视和其他周边阅读障碍方面的损害，知觉、注意力和认知/语言机制，视觉单词识别和阅读，以及2）指定神经解剖学不同形式的赤字的相关性。作为这项努力的一部分我们将评估一组关于表示的假设，通过正常视觉单词识别的空间结构处理系统，以及如何选择性地破坏这一复杂过程的一部分，导致了我们观察到的忽视和其他边缘性阅读障碍。为了解决这些问题，我们建议实施一个两阶段的计划， research. 第一阶段将包括管理一个广泛的一系列的测试，以脑损伤患者的临床症状，在阅读或其他任务（如行）中的单侧视觉忽视取消）和其他形式的外周阅读障碍患者;阶段 II将包括对个别患者的高度详细的调查他们表现出不同水平的相对选择性缺陷，在视觉单词识别的早期阶段进行处理。一期将作为将患者初步“分类“为亚型对应于忽视型阅读障碍或其他边缘型阅读障碍预测的视觉单词识别的多阶段模型。第二阶段将作为检验以下具体假设的基础：注意力、知觉和认知/语言成分的运作在不同的代表级别。两个阶段的结果将是用于探索关于神经解剖学相关性的假设，忽视阅读障碍的不同亚型及其处理机制与这些形式的忽视有关。简而言之，拟议的调查应提供重要证据，我们的理解：1）各种形式的临床表现忽视和其他周边阅读障碍; 2）的性质和组织知觉、注意力和认知/语言过程阅读; 3）可能的神经解剖学相关的假设视觉单词识别系统的组成部分;以及4）关系不同形式的忽视型阅读障碍和更普遍的单侧空间忽略