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GENETICS OF T-LYMPHOCYTE ANTIGEN RECEPTORS

GENETICS OF T-LYMPHOCYTE ANTIGEN RECEPTORS
T 淋巴细胞抗原受体的遗传学
批准号:
3133165
负责人:
EDWARD PALMER
金额:
$12.5万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-09-01 至 1988-08-31

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中文摘要
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英文摘要
We plan to study the genetics of antigen recognition in T lymphocytes using T cell hybridomas, anti-receptor antibodies and DNA probes for receptor genes. Our general approach is to examine the V genes in hybridomas of known specificity and those of related specificity in order to correlate receptor structure with Ag/MHC recognition. Specific projects include mapping the beta locus on chromosome 6, examination of V genes in hybridomas which recognize a conventional antigen (ovalbumin) or an alloantigen (I-Ab), or a self-antigen (Dd). We will plan to sequence an alpha chain polypeptide in order to clone genes in this locus. Finally, we propose to examine receptor expression in the developing thymus. Ultimately, we hope to better understand how Ag/MHC recognition is encoded in the genome.
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CONSEQUENCES OF A T CELL RECEPTOR B CHAIN GENE DELETION
  • 批准号:
    3157913
  • 项目类别:
  • 资助金额:
    $14.71万
  • 财政年份:
    1986
  • 负责人:
    EDWARD PALMER
  • 依托单位:
CONSEQUENCES OF A T CELL RECEPTOR B CHAIN GENE DELETION
  • 批准号:
    3157915
  • 项目类别:
  • 资助金额:
    $16.67万
  • 财政年份:
    1986
  • 负责人:
    EDWARD PALMER
  • 依托单位:
GENETICS OF AUTOIMMUNITY
  • 批准号:
    3157916
  • 项目类别:
  • 资助金额:
    $21.6万
  • 财政年份:
    1986
  • 负责人:
    EDWARD PALMER
  • 依托单位:
CONSEQUENCES OF A T CELL RECEPTOR B CHAIN GENE DELETION
  • 批准号:
    3157914
  • 项目类别:
  • 资助金额:
    $14.66万
  • 财政年份:
    1986
  • 负责人:
    EDWARD PALMER
  • 依托单位:
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