Role of MRL proteins in cell proliferation and migration in vivo

MRL蛋白在体内细胞增殖和迁移中的作用

• 批准号: BB/J000590/1
• 负责人: Matthias Krause
• 金额: $ 71.36万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FJ000590%2F1
• 关键词: Role; MRL; proteins; cell; proliferation

During mammalian embryonic development cells migrate through the developing body in order to form some of the tissues. Many cells proliferate and migrate along specific pathways throughout the embryo but better understanding of pathfinding mechanisms are necessary. During cancer progression, cancer cells also proliferate and migrate through tissues and form metastases, the most common reason for cancer deaths. Therefore, it is of fundamental importance to understand how cell proliferation and migration through tissues is regulated in vivo. We have evidence that MRL proteins (Lpd, RIAM) are implicated in regulating cell proliferation and cell migration. We propose to analyze their role in signal transduction cascades regulating proliferation and migration. Furthermore, we will study the role of Lpd and RIAM in cell migration in live cell imaging experiments in vivo. These experiments will give valuable insights in signal transduction cascades controlling cell proliferation and cell migration in vivo.

在哺乳动物胚胎发育过程中，细胞通过发育的身体迁移，以形成一些组织。许多细胞在整个胚胎中沿着特定的路径增殖和迁移，但有必要更好地了解路径发现机制。在癌症进展过程中，癌细胞也会在组织中扩散和迁移，形成转移，这是癌症死亡的最常见原因。因此，了解细胞在体内如何在组织中增殖和迁移是非常重要的。我们有证据表明，MRL蛋白(LPD、RIAM)与调节细胞增殖和细胞迁移有关。我们建议分析它们在调节增殖和迁移的信号转导级联中的作用。此外，我们还将在活体细胞成像实验中研究LPD和RIAM在细胞迁移中的作用。这些实验将为体内控制细胞增殖和细胞迁移的信号转导级联提供有价值的见解。

项目成果

Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice.

脑特异性层状蛋白敲除导致小鼠的多动症和焦虑增加。

• DOI: 10.1038/s41598-017-05043-3
• 发表时间: 2017-07-14
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Bodo C;Fernandes C;Krause M
• 通讯作者: Krause M

Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration.

• DOI: 10.1038/s41467-021-25916-6
• 发表时间: 2021-09-28
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Law AL;Jalal S;Pallett T;Mosis F;Guni A;Brayford S;Yolland L;Marcotti S;Levitt JA;Poland SP;Rowe-Sampson M;Jandke A;Köchl R;Pula G;Ameer-Beg SM;Stramer BM;Krause M
• 通讯作者: Krause M

Lamellipodin-RICTOR Signaling Mediates Glioblastoma Cell Invasion and Radiosensitivity Downstream of EGFR.

• DOI: 10.3390/cancers13215337
• 发表时间: 2021-10-24
• 期刊: Cancers
• 影响因子: 5.2
• 作者: Moritz S;Krause M;Schlatter J;Cordes N;Vehlow A
• 通讯作者: Vehlow A

Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration

Nance-Horan 综合征样 1 蛋白负向调节 Scar/WAVE-Arp2/3 活性并抑制片状伪足稳定性和细胞迁移

• DOI: 10.1101/2020.05.11.083030
• 发表时间: 2020
• 作者: Law A

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.

• DOI: 10.1038/onc.2016.47
• 发表时间: 2016-09-29
• 期刊: Oncogene
• 影响因子: 8