The MC-Degradome; a gas-sensing proteome that controls plant development?

MC-降解组；

• 批准号: BB/M007820/1
• 负责人: Michael Holdsworth
• 金额: $ 48.31万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM007820%2F1
• 关键词: MC; Degradome; gas; sensing; proteome

Why is it that the life of some proteins is very short, but can sometimes become longer? This proposal focuses on uncovering the mechanisms controlling the stability of proteins, particularly in response to two gases, oxygen, and the signalling molecule nitric oxide (NO). We will discover proteins that require a lack of oxygen or NO to become stable. This is important because there are examples of times during the plant life-cycle, and in response to changes in the environment (for example during flooding) when it is essential that plants can perceive a lack of oxygen or NO. This work will uncover the molecular processes that allow plants to respond to gases and provide molecular resources and conceptual frameworks that plant breeders and growers can use to change plant traits and make plants more adapted to climate change.

为什么有些蛋白质的寿命很短，但有时却可以变长？这一建议的重点是揭示控制蛋白质稳定性的机制，特别是对两种气体，氧气和信号分子一氧化氮（NO）的反应。我们将发现需要缺氧或一氧化氮才能稳定的蛋白质。这一点很重要，因为在植物的生命周期中，在应对环境变化（例如在洪水期间）的时候，植物可以感知到氧气或NO的缺乏。这项工作将揭示使植物对气体作出反应的分子过程，并为植物育种者和种植者提供分子资源和概念框架，以改变植物性状，使植物更适应气候变化。

项目成果

The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development.

• DOI: 10.1111/nph.16477
• 发表时间: 2021-01
• 期刊: The New phytologist
• 作者: Labandera AM;Tedds HM;Bailey M;Sprigg C;Etherington RD;Akintewe O;Kalleechurn G;Holdsworth MJ;Gibbs DJ
• 通讯作者: Gibbs DJ

A Yeast-Based Functional Assay to Study Plant N-Degron - N-Recognin Interactions.

• DOI: 10.3389/fpls.2021.806129
• 发表时间: 2021
• 期刊: Frontiers in plant science
• 影响因子: 5.6
• 作者: Kozlic A;Winter N;Telser T;Reimann J;Rose K;Nehlin L;Berckhan S;Sharma G;Dambire C;Boeckx T;Holdsworth MJ;Bachmair A
• 通讯作者: Bachmair A