Does the N-end rule pathway of targeted proteolysis control the plant immune system?

靶向蛋白水解的N端规则途径是否控制植物免疫系统？

• 批准号: BB/M029441/1
• 负责人: Michael Holdsworth
• 金额: $ 43.64万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM029441%2F1
• 关键词: Does; end; rule; pathway; targeted

This project will investigate the role of the N-end rule pathway of targeted proteolysis in the plant response against pathogens. Through advanced proteomics and transcriptomics approaches we aim to identify protein substrates regulated by a specific branch of the N-end rule pathway and investigate their role in the defense response. We will analyse new N-end rule associated genetic resources in barley that should increase resistance to pathogens. This work will provide evidence for a novel post-translational mechanism within the plant immune response, and resources to develop crops with increased resistance to pathogens.

本项目将研究N端规则靶向蛋白水解途径在植物抗病原体反应中的作用。通过先进的蛋白质组学和转录组学的方法，我们的目标是确定蛋白质底物的N-末端规则途径的特定分支调节，并调查他们在防御反应中的作用。我们将分析新的N-末端规则相关的大麦遗传资源，应该增加对病原体的抗性。这项工作将为植物免疫反应中的一种新的翻译后机制提供证据，并为开发对病原体具有更高抗性的作物提供资源。

项目成果

Additional file 2: of Hypoxia response in Arabidopsis roots infected by Plasmodiophora brassicae supports the development of clubroot

附加文件2：受芸苔根肿菌感染的拟南芥根部的缺氧反应支持根肿病的发育

• DOI: 10.6084/m9.figshare.c.3599162_d2
• 发表时间: 2016
• 作者: Gravot A

The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development.

• DOI: 10.1111/nph.16477
• 发表时间: 2021-01
• 期刊: The New phytologist
• 作者: Labandera AM;Tedds HM;Bailey M;Sprigg C;Etherington RD;Akintewe O;Kalleechurn G;Holdsworth MJ;Gibbs DJ
• 通讯作者: Gibbs DJ

Additional file 4: of Hypoxia response in Arabidopsis roots infected by Plasmodiophora brassicae supports the development of clubroot

附加文件 4：受芸苔根肿菌感染的拟南芥根部缺氧反应支持根肿病的发育

• DOI: 10.6084/m9.figshare.c.3599162_d4
• 发表时间: 2016
• 作者: Gravot A

Additional file 1: of Hypoxia response in Arabidopsis roots infected by Plasmodiophora brassicae supports the development of clubroot

附加文件 1：受芸苔根肿菌感染的拟南芥根部缺氧反应支持根肿病的发育

• DOI: 10.6084/m9.figshare.c.3599162_d3
• 发表时间: 2016
• 作者: Gravot A

Additional file 3: of Hypoxia response in Arabidopsis roots infected by Plasmodiophora brassicae supports the development of clubroot

附加文件 3：受芸苔根肿菌感染的拟南芥根部缺氧反应支持根肿病的发育

• DOI: 10.6084/m9.figshare.c.3599162_d1
• 发表时间: 2016
• 作者: Gravot A