A Combinatorial Approach to Enhance Production of Monoclonal Antibodies

提高单克隆抗体产量的组合方法

• 批准号: BB/M018237/1
• 负责人: Robert White
• 金额: $ 349.19万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM018237%2F1
• 关键词: Combinatorial; Approach; Enhance; Production; Monoclonal

Biopharmaceuticals, also known as biologic medical products (biologics for short) are medicinal products manufactured in or extracted from biological systems and are distinct from synthesized pharmaceutical products. Examples include vaccines against diseases such as polio and therapeutics used to treat numerous diseases, such as cancer and arthritis. These therapeutics are often molecules called monoclonal antibodies that are made by the immune system, our inbuilt anti-disease defense mechanism. Perhaps one the best known examples of this is Trastuzumab (trade name; Herceptin), a monoclonal antibody that is used to treat certain breast cancers. Production of these biologics is expensive and this translates into a high financial cost to health care providers.This project aims to alter the cells that make monoclonal antibodies for therapeutic use, so that they make larger amounts with reduced production costs. This should increase the availability of these powerful therapeutics.

生物制药，也称为生物医疗产品（简称生物制剂），是在生物系统中制造或从生物系统中提取的药品，与合成药品不同。例子包括针对脊髓灰质炎等疾病的疫苗，以及用于治疗癌症和关节炎等多种疾病的疗法。这些治疗方法通常是被称为单克隆抗体的分子，由免疫系统产生，免疫系统是我们体内的抗疾病防御机制。也许最著名的例子是曲妥珠单抗（商品名；赫赛汀），一种用于治疗某些乳腺癌的单克隆抗体。这些生物制剂的生产成本高昂，这对卫生保健提供者来说意味着高昂的财务成本。该项目旨在改变制造单克隆抗体用于治疗的细胞，使它们以更低的生产成本生产更多的单克隆抗体。这应该会增加这些强效疗法的可用性。

项目成果

Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors.

• DOI: 10.1038/s41467-017-01222-y
• 发表时间: 2017-10-30
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Kleinjan DA;Wardrope C;Nga Sou S;Rosser SJ
• 通讯作者: Rosser SJ

Leveraging glycomics data in glycoprotein 3D structure validation with Privateer.

• DOI: 10.3762/bjoc.16.204
• 发表时间: 2020
• 期刊: Beilstein journal of organic chemistry
• 影响因子: 2.7
• 作者: Bagdonas H;Ungar D;Agirre J
• 通讯作者: Agirre J

Molecular architecture of the complete COG tethering complex.

• DOI: 10.1038/nsmb.3263
• 发表时间: 2016-08
• 期刊: Nature structural & molecular biology
• 影响因子: 16.8
• 作者: Ha JY;Chou HT;Ungar D;Yip CK;Walz T;Hughson FM
• 通讯作者: Hughson FM