B-ENDORPHIN (B-EP) ANALOG SYNTHESIS AND B-EP RECEPTORS

B-内啡肽 (B-EP) 类似物合成和 B-EP 受体

• 批准号: 3209402
• 负责人: CHOH H LI
• 金额: $ 10.62万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-01-01 至 1988-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3209402
• 关键词: affinity labeling; analgesics; brain; cell membrane; chromatography; density gradient ultracentrifugation; drug design /synthesis /production; drug metabolism; electrofocusing; endorphins; gel electrophoresis; glioma; hybrid cells; laboratory mouse; laboratory rat; neuroblastoma; neuropeptide receptor; neuropharmacology; peptide analog; photochemistry; radiotracer

项目成果

Chemical synthesis of human beta-endorphin(1-27) analogs by peptide segment coupling. Leucine and glycine residues bearing thiocarboxyl functions as junctions for peptide segment coupling.

通过肽段偶联化学合成人 β-内啡肽 (1-27) 类似物。

• 发表时间: 1991
• 期刊: International journal of peptide and protein research
• 作者: Cheng,HC;Yamashiro,D
• 通讯作者: Yamashiro,D

Synthesis and receptor binding activity of elephant beta-endorphin, a beta-endorphin homolog with highly potent analgesic activity.

大象β-内啡肽（一种具有高效镇痛活性的β-内啡肽同系物）的合成和受体结合活性。

• DOI: 10.1111/j.1399-3011.1991.tb01411.x
• 发表时间: 1991
• 期刊: International journal of peptide and protein research
• 作者: Cheng,HC;Yamashiro,D
• 通讯作者: Yamashiro,D