NEUROMOTOR FUNCTIONING IN COCAINE-EXPOSED INFANTS

这项资助的目的是评估宫内节育器的效果。 可卡因暴露对神经运动发育和功能的影响 使用运动学分析的第一年生命。运动学分析， 这项研究是一个复杂的系统婚礼红外，视频， 计算机技术，能够客观和精确地量化 直到最近， 临床术语我们认为可卡因中的神经运动功能障碍 与未暴露婴儿相比，暴露婴儿将通过 构成一个乐章的组成单元的数量增加， 速度和加速度的异常模式， 运动路径的混乱，自然的延伸 运动阶段之间的停顿。这些影响被认为是 与脑损伤有关 这项研究是一项纵向前瞻性研究， 有记录的宫内暴露于可卡因的婴儿， 一组是40名没有违法史的婴儿， 暴露于非法物质。研究中的所有婴儿都将 新生儿病程平稳， 身高、体重和头围的百分位数。在新生儿 期间，他们的运动模式将被评估与运动学 在无生命的视听定向项目的分析， 新生儿行为评估量表（NBAS）。在7个月和15个月时， 婴儿的运动模式将在一个运动学评估过程中， 达成任务。婴儿也将与运动进行评估 7个月婴儿评估和Bayley婴儿量表 7个月和15个月时的发育。

The goal of this grant is to evaluate the effects of intrauterine cocaine exposure on neuromotor development and functioning over the first year of life using kinematic analysis. Kinematic analysis, in this study a sophisticated system wedding infrared, video, and computer technology, is able to objectively and precisely quantify the parameters of movement that until recently could only by described in clinical terms. We expect that neuromotor dysfunction in the cocaine exposed infants compared to non-exposed infants will be evidenced by an increase in the number of component units making up a movement, aberrant patterns of velocities and accelerations, disruption and disorganization of the path of movement, and elongation of the natural pauses between movement phases. These effects are found to be associated with brain damage. The proposed study is a longitudinal prospective study of forty infants with documented intrauterine exposure to cocaine, and no other illicit substances, and a matched group of 40 infants with no history of exposure to illicit substances. All infants in the study will have had an uneventful neonatal course and will be above the 10th percentile for height, weight, and head circumference. In the neonatal period, their movement patterns will be assessed with kinematic analysis during the inanimate visual-auditory orientation item of the Neonatal Behavioral Assessment Scale (NBAS). At 7 and 15 months, infant movement patterns will be kinematically assessed during a reaching task. The infants will also be evaluated with the Movement Assessment of Infants at 7 months, and the Bayley Scales of Infant Development at 7 and 15 months.