NEUROMOTOR FUNCTIONING IN COCAINE-EXPOSED INFANTS

这笔赠款的目的是评估宫内注射的效果。 可卡因暴露对神经运动发育和功能的影响 使用运动学分析的生命第一年。运动学分析，在 这项研究是一个复杂的系统，婚礼红外线，视频，和 计算机技术，能够客观而准确地量化 直到最近才能描述的运动参数 临床术语。我们预计可卡因引起的神经运动功能障碍 接触过病毒的婴儿与未接触过病毒的婴儿相比，将通过以下方式得到证明 构成运动的组成单元的数量的增加， 速度和加速度的反常模式，干扰和 运动路径的解体，以及自然的伸长 在移动阶段之间暂停。这些影响被发现是 与脑损伤有关。 这项拟议的研究是一项纵向前瞻性研究，共有40人 有记录的宫内暴露于可卡因的婴儿，没有其他 非法物质，以及一组40名无病史的婴儿 暴露于非法物质的风险。研究中的所有婴儿都会有 有一个平淡无奇的新生儿过程，将在10岁以上 身高、体重和头围的百分位数。在新生儿中 期间，它们的运动模式将通过运动学进行评估 在无生命视听定向项目中的分析 新生儿行为评定量表(NBAS)。在7个月和15个月时， 婴儿的运动模式将在一个 正在完成任务。这些婴儿也将接受该运动的评估 婴儿出生后7个月的评估和贝利婴儿量表 在7个月和15个月时发育。

The goal of this grant is to evaluate the effects of intrauterine cocaine exposure on neuromotor development and functioning over the first year of life using kinematic analysis. Kinematic analysis, in this study a sophisticated system wedding infrared, video, and computer technology, is able to objectively and precisely quantify the parameters of movement that until recently could only by described in clinical terms. We expect that neuromotor dysfunction in the cocaine exposed infants compared to non-exposed infants will be evidenced by an increase in the number of component units making up a movement, aberrant patterns of velocities and accelerations, disruption and disorganization of the path of movement, and elongation of the natural pauses between movement phases. These effects are found to be associated with brain damage. The proposed study is a longitudinal prospective study of forty infants with documented intrauterine exposure to cocaine, and no other illicit substances, and a matched group of 40 infants with no history of exposure to illicit substances. All infants in the study will have had an uneventful neonatal course and will be above the 10th percentile for height, weight, and head circumference. In the neonatal period, their movement patterns will be assessed with kinematic analysis during the inanimate visual-auditory orientation item of the Neonatal Behavioral Assessment Scale (NBAS). At 7 and 15 months, infant movement patterns will be kinematically assessed during a reaching task. The infants will also be evaluated with the Movement Assessment of Infants at 7 months, and the Bayley Scales of Infant Development at 7 and 15 months.