LIVER TRANSPLANTATION: ENCEPHALOPATHY, IS IT REVERSIBLE?

肝移植是一种日益被接受的治疗方法 肝病的种类。慢性或晚期肝病频发 会导致脑病，但到目前为止，还没有进行过研究 已经确定了移植是否会导致功能恢复 从这种神经紊乱中。 拟议的调查将：1)阐明 慢性肝性脑病；2)连续监测证型， 两年后测量的脑病的变化幅度 肝移植；3)阐明两者之间的联系 肝病的生化特征及肝脏形态 脑病的特征和，4)决定是否生化和 肝脏形态特征可预测功能恢复率 肝移植后脑病的康复。 80名肝移植患者将与40名患者进行比较 消化性溃疡手术治疗与80例正常社区居民 个人。受试者将在四个匹配的场合进行检查 尽可能地靠得更近。评估时间表为：a) 移植前；b)移植后三个月；c)一年 移植后；以及d)移植后两年。在每一个上 在此情况下，受试者将接受全面的医学和实验室 体检，以及广泛的神经精神病学评估。 这项研究的长期目标是阐明 特点和从肝性脑病恢复的潜力，以及 目的：探讨肝移植修复肝功能障碍的疗效。 一个人过上富有成效和健康的生活。

Liver transplantation is an increasingly accepted treatment for certain types of hepatic disease. Chronic or advanced hepatic illness frequently causes encephalopathy, but as yet, there have been no studies conducted which have determined if transplantation results in functional recovery from this neurological disorder. The proposed investigation will: 1) elucidate the characteristics of chronic hepatic encephalopathy; 2) serially monitor the pattern and magnitude of change in measured encephalopathy for two years following hepatic transplantation; 3) elucidate the association between the biochemical characteristics of hepatic illness as well as liver morphology characteristics on encephalopathy and, 4) determine if the biochemical and liver morphology characteristics can predict the rate of functional recovery from encephalopathy after liver transplantation. Eighty liver transplantation patients will be compared to forty patients undergoing surgery for peptic ulcer and to eighty normal community dwelling individuals. The subjects will be examined on four occasions matched as closely as possible to each other. The schedule of evaluation is: a) pre-transplantation; b) three months post-transplantation; c) one year post-transplantation; and d) two years post-transplantation. On each occasion, the subjects will receive a comprehensive medical and laboratory workup, as well as an extensive neuropsychiatric assessment. The long term objectives of this research are to elucidate the characteristics and potential for recovery from hepatic encephalopathy, and to determine the efficacy of hepatic transplantation in restoring the person to a productive and healthy life.