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ULTRASONIC ABSORPTION BY BIOLOGICAL MATERIALS

生物材料对超声波的吸收

基本信息

批准号：
3268370
负责人：
FLOYD DUNN
金额：
$ 11.8万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
1974
资助国家：
美国
起止时间：
1974-09-01 至 1988-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3268370
关键词：
biomaterials diagnostic tests sound impedance stereochemistry tissue /cell culture tissues ultrasound biological effect

项目摘要

Studies are conducted to obtain detailed understanding of the ultrasonic propagation properties of biological systems, with immediate emphasis on ultransonic absorption, attenuation, and velocity dispersion in mammalian tissues and organs and in solutions and suspensions of important biological macromolecules. Specific objectives are: (1) measurement of absorption and velocity of ultrasonic waves in tissues and in solutions of biopolymers, (2) identification of the physical parameters important for describing the observed behavior, (3) quantitative interpretation of the phenomena in terms of relaxation and/or other processes, and (4) continued development of appropriate instrumentation for obtaining the necessary experimental data. The attainment of these objectives contributes to an understanding of the physical mechanisms of interaction of sound and biological systems, which must be elucidate before the full potential of the ultrasonic techniques will be realized for medical diagnostic and therapeutic applications and for biochemical and biophysical investigation of fast reactions. The results of the investigations also contribute important associated with toxic effects and dosimetry of clinical ultrasound. Recent findings include the role of water and structural proteins in determining the propagation properties, in vivo measurements of absorption over wide ranges of temperature and frequency, propagation properties of lung, the influence of autolysis and fixation on attenuation, scattering and velocity, the influence of concentration on absorption, and the development of a small volume resonant instrument for determining absorption and velocity.

进行研究以获得对超声波的详细了解生物系统的传播特性，立即强调哺乳动物的超声波吸收、衰减和速度色散组织和器官以及重要生物的溶液和悬浮液大分子。具体目标是：（1）测量吸收和超声波在组织和生物聚合物溶液中的速度，(2) 识别对于描述观察到的现象很重要的物理参数行为，（3）对现象的定量解释放松和/或其他过程，以及（4）持续发展适当的获得必要的实验数据的仪器。所取得的成就这些目标有助于理解物理机制声音和生物系统的相互作用，在之前必须阐明超声波技术的全部潜力将在医疗领域得到充分发挥诊断和治疗应用以及生物化学和生物物理快速反应的研究。调查结果还与临床毒性作用和剂量测定相关的重要贡献超声波。最近的发现包括水和结构蛋白的作用在确定传播特性时，体内吸收测量在广泛的温度和频率范围内，肺的传播特性，自溶和固定对衰减、散射和速度的影响，浓度对吸收的影响，以及小分子的发展用于确定吸收和速度的体积共振仪。