MECHANISMS OF HEXOSE EPIMERASES AND OXIDOREDUCTASES

一系列的酶学、立体化学和机械学研究 提出了己糖代谢中导致还原的反应 羟基被氢取代和异构化 碳水化合物链上的手性中心。这些研究将涉及 参与岩藻糖生物合成的GDP-甘露糖氧化还原酶反应，与 沙门氏菌CDP-4-酮-6-脱氧葡萄糖3-还原酶系统 在几种链霉菌中形成2，6-双脱氧己糖，与 植物将国内生产总值-甘露糖向国内生产总值-L-半乳糖(和国内生产总值-L-岩藻糖)的异构化 酶，D-甘露糖醛酸异构化为L古糖醛酸 褐藻酸形成过程中的残留物。

A series of enzymological, stereochemical and mechanistic studies are proposed on reactions in hexose metabolism, which lead to the reductive replacement of hydroxyl groups by hydrogen and to the epimerization of chiral centers in the carbohydrate chain. These studies will deal with the GDP-mannose oxidoreductase reaction involved in fucose biosynthesis, with the CDP-4-keto-6-deoxyglucose 3-reductase system from Salmonella, with the formation of 2,6-dideoxyhexoses in several streptomyces, with the epimerization of GDP-mannose to GDP-L-galactose (and GDP-L-fucose) by plant enzymes, and with the epimerization of D mannuronic to L guluronic acid residues in the course of alginic acid formation.