MECHANISMS OF HEXOSE EPIMERASES AND OXIDOREDUCTASES

本文对该酶的酶学、立体化学和作用机理进行了一系列的研究。 提出的反应在己糖代谢，这导致还原 羟基被氢取代以及 糖链中的手性中心。 这些研究将涉及 参与岩藻糖生物合成的GDP-甘露糖氧化还原酶反应， 来自沙门氏菌的CDP-4-酮基-6-脱氧葡萄糖3-还原酶系统，具有 在几种链霉菌中形成2，6-二脱氧己糖， 通过植物将GDP-甘露糖差向异构化为GDP-L-半乳糖（和GDP-L-岩藻糖） 酶，并与D甘露糖醛酸的差向异构化L古洛糖醛酸 在海藻酸形成过程中的残留物。

A series of enzymological, stereochemical and mechanistic studies are proposed on reactions in hexose metabolism, which lead to the reductive replacement of hydroxyl groups by hydrogen and to the epimerization of chiral centers in the carbohydrate chain. These studies will deal with the GDP-mannose oxidoreductase reaction involved in fucose biosynthesis, with the CDP-4-keto-6-deoxyglucose 3-reductase system from Salmonella, with the formation of 2,6-dideoxyhexoses in several streptomyces, with the epimerization of GDP-mannose to GDP-L-galactose (and GDP-L-fucose) by plant enzymes, and with the epimerization of D mannuronic to L guluronic acid residues in the course of alginic acid formation.