PH-SENSITIVE HYDROGELS FOR DRUG RELEASE

制定pH敏感、溶胀- 用于递送药物的控释系统、双分子和 研究了基因工程分子。 新系统是 由可在水中溶胀的亲水性、离子性、玻璃状聚合物制成 或生物液体。 水溶性溶质扩散的机理 最初玻璃状、连续溶胀的亲水聚合物体系 研究了 实验研究进行了交联 甲基丙烯酸2-羟乙酯与甲基丙烯酸、N-乙烯基- 吡咯烷酮和各种丙烯酰胺，使用几种低或高浓度的溶质， 分子量的 研究了交联度和动态力学性能的影响 研究了聚合物的溶胀行为对溶质扩散的影响， 扩散/溶解/切片/显微镜检查/应力组合 放松实验 网孔尺寸通过以下实验确定： 平衡溶胀研究。 建立了pH敏感性模型 这些水凝胶的溶胀度和动态溶胀。

Development of guidelines for the design of pH-sensitive, swelling- controlled release systems for delivery of drugs, bimolecules and genetically-engineered molecules is investigated. The novel systems are produced from hydrophilic, ionic, glassy polymers which can swell in water or biological fluids. Mechanisms of water-soluble solute diffusion through initially glassy, continuously swelling hydrophilic polymer systems are investigated. Experimental studies are performed with crosslinked copolymers of 2-hydroxyethyl methacrylate with methacrylic acid, N-vinyl- pyrrolidone and various acrylamides using several solutes of low or high molecular weight. The effect of degree of crosslinking and dynamic swelling behavior of the polymer on solute diffusion are studied with a combination of diffusion/dissolution/microtoming/microscopy/stress relaxation experiments. The mesh size is determined experimentally by equilibrium swelling studies. Models are developed for the pH sensitivity of the degree of swelling and the dynamic swelling of these hydrogels.