PH SENSITIVE COMPLEX HYDROGELS AND IPNS FOR DRUG RELEASE

用于药物释放的 PH 敏感复合水凝胶和 IPNS

• 批准号: 2181964
• 负责人: NICHOLAS A PEPPAS
• 金额: $ 10.73万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-12-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2181964
• 关键词: acidity /alkalinity; diltiazem; drug delivery systems; drug design /synthesis /production; ethylene glycols; gel; hydropathy; infrared spectrometry; interferometry; ionic strengths; nuclear magnetic resonance spectroscopy; polymers; polymethacrylate; solutions; temperature; theophylline

Novel carriers for controlled delivery of drugs are prepared from hydrogels that have the ability to respond to pH, ionic strength, composition of physiological solution and temperature. Such hydrogels can be used for abrupt release of drugs or proteins at constant rates. We propose to develop graft copolymers of poly(ethylene glycol) with poly(methacrylic acid), which can complex by hydrogen bonding. Upon loading these systems with drugs or proteins and upon abruptly changing the pH of the surrounding solution from acidic to basic it is possible to decomplex the network leading to sudden drug release. An alternative release system based on interpenetrating polymeric networks of complexing is also developed. Finally, pH-sensitive hydrogels of poly(hydroxyethyl acrylic acid) are synthesized in the presence of water at concentrations larger than the equilibrium concentrations of the corresponding gels. When these systems are loaded with drugs or proteins and swollen in constant pH solutions, they deswell (collapse) transforming the polymer system into a highly porous gel. Thus, the incorporated drugs can be released at constant rates. The release process is dependent on the pH and temperature of the solution. Experimental studies of drug release from such systems will be carried out and the overall release behavior will be model led.

用于药物控制递送的新型载体由以下物质制备： 具有响应pH，离子强度， 生理溶液的组成和温度。 这样的水凝胶可以 用于药物或蛋白质以恒定速率的突然释放。 我们 建议开发聚乙二醇与 聚（甲基丙烯酸），其可通过氢键络合。 后 在这些系统中装载药物或蛋白质， 将周围溶液的pH从酸性变为碱性， 使网络分解导致药物突然释放。 一个替代 基于络合的互穿聚合物网络的释放系统 也是发达的。 最后，pH敏感的聚（羟乙基）水凝胶， 丙烯酸）在水的存在下合成， 大于相应凝胶的平衡浓度。 当这些系统装载药物或蛋白质并膨胀时， 恒定pH值溶液，它们使聚合物变形（塌陷）， 系统成高度多孔的凝胶。 因此，掺入的药物可以是 以恒定速率释放。 释放过程取决于pH值 和溶液的温度。 药物释放的实验研究 从这样的系统将进行和整体释放行为 将由模型主导。