REGULATION OF XENOPUS HISTONE GENE TRANSCRIPTION

胚胎发育和分化受到控制，直接和 间接地，通过基因表达模式的变化。它是 有兴趣了解监管信号机制和变化 其中，对于其活动与特定状态相关的基因 胚胎发育或分化。我建议调查各位议员 属于多基因家族，编码组蛋白，受不同的 卵子发生和早期胚胎的转录调控模式 发展。这个基因家族提供了一种方便的模型来研究 胚胎发育中基因表达的控制，因为它们是 第一个在许多动物胚胎中被激活的。这次会议的主要目标是 提案旨在阐明所需的基因近端调控信号 组蛋白基因在胚胎发育早期的转录，以研究一种 组蛋白基因转录在早期胚胎中的调控转变 发展和探索协调背后的机制 转录该基因家族的代表性成员的转录

Embryonic development and differentiation is controlled, directly and indirectly, by changes in the patterns of gene expression. It is of interest to understand regulatory signaling mechanisms, and changes therein, for genes whose activities are related to particular states of embryonic development or differentiation. I propose to investigate members of a multigene family, encoding histones, that are subject to distinct modes of transcriptional regulation during oogenesis and early embryonic development. This gene family provides a convenient model to examine the control of gene expression in embryonic development since they are among the first to be activated in many animal embryos. The major goals of this proposal are to elucidate the gene-proximal regulatory signal required for histone gene transcription early in embryogenesis, to investigate a regulatory transition in histone gene transcription during early embryonic development and to explore the mechanisms underlying the coordinate transcription of representative members of this gene family.