REGULATION OF XENOPUS HISTONE GENE TRANSCRIPTION

胚胎的发育和分化是直接和 通过基因表达模式的改变间接地改变。 具有 有兴趣了解调控信号机制， 其中，对于其活动与特定状态相关的基因， 胚胎发育或分化。 我提议调查 一个多基因家族，编码组蛋白，受到不同的 卵子发生和胚胎早期的转录调控模式 发展 这个基因家族提供了一个方便的模型来检查 控制基因表达的胚胎发育，因为它们是 在许多动物胚胎中首先被激活。 本项目的主要目标是 建议是阐明基因近端调控信号所需的 在胚胎发生早期，组蛋白基因转录，以探讨一个 胚胎早期组蛋白基因转录调控转变 发展和探讨协调的机制 该基因家族的代表性成员的转录。

Embryonic development and differentiation is controlled, directly and indirectly, by changes in the patterns of gene expression. It is of interest to understand regulatory signaling mechanisms, and changes therein, for genes whose activities are related to particular states of embryonic development or differentiation. I propose to investigate members of a multigene family, encoding histones, that are subject to distinct modes of transcriptional regulation during oogenesis and early embryonic development. This gene family provides a convenient model to examine the control of gene expression in embryonic development since they are among the first to be activated in many animal embryos. The major goals of this proposal are to elucidate the gene-proximal regulatory signal required for histone gene transcription early in embryogenesis, to investigate a regulatory transition in histone gene transcription during early embryonic development and to explore the mechanisms underlying the coordinate transcription of representative members of this gene family.