HUMAN DECIDUA AND FETAL MEMBRANES AS A PARACRINE SYSTEM
HUMAN DECIDUA AND FETAL MEMBRANES AS A PARACRINE SYSTEM
批准号:
3324809
负责人:
Gillian Doreen Bryant-Greenwood
金额:
$13.78万
依托单位国家:
美国
项目类别:
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-01-01 至 1995-12-31
关键词:
RNase protection assay amnion autoradiography birth chorioallantoic membrane collagenase decidua embryo /fetus membrane endometrium enzyme inhibitors extracellular matrix gene expression hormone receptor hormone regulation /control mechanism human tissue immunocytochemistry in situ hybridization messenger RNA northern blottings paracrine placenta plasminogen activator proteolysis relaxin secretion tissue /cell culture
中文摘要
人蜕膜/胎膜系统的潜力是可触及的
英文摘要
The potential of the human decidua/fetal membrane system as an accessible
autocrine/paracrine model will be further explored, in order to elucidate
the role of relaxins in the local control of collagenolysis and the rupture
of the fetal membranes at parturition. An added challenge is our finding
that the second human relaxin gene (H1) is expressed in this system.
This will be accomplished by studying the four components of the relaxin
system: gene expression, control of secretion, biological effects and
receptor distribution.
Relaxin H1 and H2 gene expression and the translated products, will be
identified in the endometrium/decidua, fetal membranes and placenta with
specific riboprobes and antibodies throughout the cycle and pregnancy.
The effect on decidual cell relaxin secretion and the mRNA levels for
relaxins by a range of decidual and placental hormones will be studied in
in vitro.
The biological effects of human relaxin H2 on fetal membrane/decidual
production of key collagenolytic enzymes and inhibitors will be sought both
in vitro and in vivo.
Changes in the concentration of relaxin receptors in intrauterine tissues
will be studied through the cycle and gestation by quantitative
autoradiography and the results related to those from the experiments
above.
The combined results will provide insights into significant problems, the
local control of the accommodation of the fetal membranes to the growing
fetus in the last weeks of pregnancy, and the timing of normal spontaneous
membrane rupture. These studies will lead to a greater understanding of
premature rupture of the fetal membranes, a major cause of premature birth
which results in infants with a high incidence of neurodevelopmental
impairment.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
PATHWAYS TO PRE-TERM BIRTH
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批准号:7380988
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项目类别:
-
资助金额:$5.31万
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财政年份:2006
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
PROTEINS IN MATERNAL SERUM ASSOCIATED WITH THE PREECLAMPSIA
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批准号:7167027
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项目类别:
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资助金额:$23.52万
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财政年份:2005
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
EQUIPMENT GRANT FOR A FLEXCELL TENSION PLUS SYSTEM
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批准号:6972104
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项目类别:
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资助金额:$3.65万
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财政年份:2004
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
RELAXIN AS A PARACRINE HORMONE
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批准号:6311602
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项目类别:
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资助金额:$2.19万
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财政年份:2000
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
NON-INFLAMMATORY RUPTURE OF THE FETAL MEMBRANE
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批准号:6221194
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项目类别:
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资助金额:$27.28万
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财政年份:1999
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
RELAXIN AS A PARACRINE HORMONE
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批准号:6107848
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项目类别:
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资助金额:$2.19万
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财政年份:1999
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
NON-INFLAMMATORY RUPTURE OF THE FETAL MEMBRANE
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批准号:6310106
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项目类别:
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资助金额:$3.26万
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财政年份:1999
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
NON-INFLAMMATORY RUPTURE OF THE FETAL MEMBRANE
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批准号:6123317
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项目类别:
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资助金额:$27.28万
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财政年份:1998
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
NON-INFLAMMATORY RUPTURE OF THE FETAL MEMBRANE
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批准号:6283118
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项目类别:
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资助金额:$27.28万
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财政年份:1998
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
RELAXIN AS A PARACRINE HORMONE
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批准号:6271900
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项目类别:
-
资助金额:$0.0万
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财政年份:1998
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
HUMAN DECIDUA AND FETAL MEMBRANES AS A PARACRINE SYSTEM
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批准号:2888963
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项目类别:
-
资助金额:$24.76万
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财政年份:1997
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
NON-INFLAMMATORY RUPTURE OF THE FETAL MEMBRANE
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批准号:6254187
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项目类别:
-
资助金额:$15.51万
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财政年份:1997
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
HUMAN DECIDUA AND FETAL MEMBRANES AS A PARACRINE SYSTEM
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批准号:6182145
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项目类别:
-
资助金额:$25.5万
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财政年份:1997
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
Decidua and Fetal Membranes as a Paracrine System
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批准号:6640015
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项目类别:
-
资助金额:$27.63万
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财政年份:1997
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
Decidua and Fetal Membranes as a Paracrine System
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批准号:6760181
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项目类别:
-
资助金额:$30.67万
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财政年份:1997
-
负责人:Gillian Doreen Bryant-Greenwood
-
依托单位:
Decidua and Fetal Membranes as a Paracrine System
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批准号:6896602
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项目类别:
-
资助金额:$30.67万
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财政年份:1997
-
负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
HUMAN DECIDUA AND FETAL MEMBRANES AS A PARACRINE SYSTEM
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批准号:2673568
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项目类别:
-
资助金额:$24.04万
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财政年份:1997
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负责人:Gillian Doreen Bryant-Greenwood
-
依托单位:
Decidua and Fetal Membranes as a Paracrine System
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批准号:7064299
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项目类别:
-
资助金额:$29.95万
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财政年份:1997
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
HUMAN DECIDUA AND FETAL MEMBRANES AS A PARACRINE SYSTEM
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批准号:2389516
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项目类别:
-
资助金额:$23.34万
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财政年份:1997
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
Decidua and Fetal Membranes as a Paracrine System
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批准号:6540906
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项目类别:
-
资助金额:$28.53万
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财政年份:1997
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负责人:Gillian Doreen Bryant-Greenwood
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依托单位:
海外基金